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<p>The Singapore National Precision Medicine (NPM) program is a three-phase whole-of-nation effort designed to develop scalable, evidence-based solutions for precision health tailored to Asia’s diverse populations. Here we present NPM phase II (2020–2025), highlighting how large-scale precision medicine initiatives can drive new research insights, enable healthcare innovations and create economic value. Key achievements include the PRECISE-SG100K population dataset, which reflects Singapore’s unique multi-ancestry Asian population; the successful translation of research findings into mainstream national healthcare using familial hypercholesterolemia as a use case; and the establishment of strategic public–private partnerships with diverse industry sectors. We also outline phase III (2025–2031), which aims to establish whole-genome sequencing as a foundational element of a patient’s lifelong healthcare record for 10% of the population. NPM provides a model for how smaller countries, despite limited populations and finite resources, can contribute meaningfully to global scientific movements while preserving strategic independence and addressing national health challenges.</p>

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Translating genomic data into healthcare practice with the Singapore National Precision Medicine program

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Shih Wee Seow,
  • Theresia Mina,
  • Maxime Hebrard,
  • Nilanjana Sadhu,
  • Claire Bellis,
  • Bitong Clarabelle Alexandrine Lin,
  • Pritesh Jain,
  • Pierre Vincent-Goy,
  • Xiaoyan Wang,
  • Pin Yan Low,
  • Tavintharan Subramaniam,
  • Sharon Pek,
  • Hwee Lin Wee,
  • Joanne Ngeow,
  • Ken Redekop,
  • Alec Morton,
  • Kar Hui Ng,
  • David Matchar,
  • Yi Wang,
  • Mikael Hartman,
  • Jingmei Li,
  • Elaine Ah Gi Lo,
  • Charlie Guan Yi Lim,
  • Jiali Yao,
  • Wei Ting Huang,
  • Clement Qiwen Sin,
  • Denise Xin Yi Chua,
  • Emily Shu Fang Lau,
  • Gloria Hoi Wan Tso,
  • Huiping Huang,
  • Janice Sin Hong Natalie Chong,
  • Jasmine Kah Bing Tan,
  • Jia En Tan,
  • Li Harn Leong,
  • Nichole Choon Ya Lim,
  • Nicole Ziyi Zhuo,
  • Yaelim Lee,
  • Yun Keng Pang,
  • Akash Bahai,
  • Benjamin Chih Chiang Lam,
  • Darwin Tay,
  • Dorrain Yanwen Low,
  • Elio Riboli,
  • Eng Sing Lee,
  • Harinakshi Sanikini,
  • Gervais Wansaicheong,
  • He Wang,
  • Hong Kiat Ng,
  • Kelvin Li,
  • Kostas Tsilidis,
  • Marie Loh,
  • Paul Elliott,
  • Rinkoo Dalan,
  • Terry Yoke Yin Tong,
  • Tock Han Lim,
  • Tricia Chang,
  • Wai Kee Kok,
  • Yik Weng Yew,
  • Linda Wei Lin Tan,
  • Rob M. van Dam,
  • Can Can Xue,
  • Miao Ling Chee,
  • Miao Li Chee,
  • Tin Aung,
  • Tien Yin Wong,
  • Yih Chung Tham,
  • Zhi Da Soh,
  • Annie Lee,
  • Jonathan Jiunn Liang Yap,
  • Siew Ching Kong,
  • Amelia Sutikna,
  • Erin Yi Ting Lin,
  • Joanna Hui Juan Tan,
  • Justin Jeyakani,
  • Khai Koon Heng,
  • Jack Ling Ow,
  • Paul Chung Pui Cheng,
  • Rodrigo Toro Jimenez,
  • Shakita Sunmugam,
  • Shimin Ang,
  • Tat Hung Koh,
  • Wee Yang Meah,
  • Xiao Yin Chen,
  • Zhicheng Xie,
  • Zhihui Li,
  • Jane Andrea Lieviant,
  • Jing Xian Teo,
  • Nellie Bin Siew Chai,
  • Wan Wan Lim,
  • Danny Ong,
  • Kevin Lam,
  • Mervin Chan,
  • Yu Li Ng,
  • Zhen Xuan Yeo,
  • Anita Sheldenkar,
  • Jack Yong Ho,
  • Jo-Anne Manski-Nankervis,
  • May Lwin,
  • Zoe Ong,
  • Angela Ballantyne,
  • Hui Jin Toh,
  • Owen Schaefer,
  • Serene Ong,
  • Yee Kwang Seck,
  • Akshar Saxena,
  • Alvin Ng,
  • Andrea Tan Wan Ling,
  • Caitlin Nicole Samy Victoria,
  • Chi Ling Chan,
  • Chia Wei Lim,
  • Claresta Yeo,
  • Dana Leng Hui Chan,
  • Diya Porwal,
  • Ee Ling Chew,
  • George Arun Devasia,
  • Isaac Zhenhan Lin,
  • Janeshi Ashwini Wijeweera,
  • Jeanette Yuen,
  • Jens Samol,
  • Jianbang Chiang,
  • Jieru Ye,
  • Soo Chin Lee,
  • Manasadevi Karthikeyan,
  • Nikita Bora,
  • Nur Diana Binte Ishak,
  • Nur Hikmah Fitriyah Binte Mohammad Rafiz,
  • Pei Yi Ong,
  • Rebecca Caeser,
  • Ruby Clarissa Sutopo,
  • Rutharra Ghayadthri Manisekaran,
  • Samuel G. W. Ow,
  • Sangeetha Shanmugam,
  • Sara Tasnim,
  • Sarah Shahrin,
  • Serene Jianglei Wu,
  • Shao-Tzu Li,
  • Siao Ting Chong,
  • Tasmyn Dale Scriven,
  • Tiffany Qing Lim,
  • Valerie Yue Ming Heong,
  • Vanna Chhay,
  • Zewen Zhang,
  • Zhi Yi Koo,
  • Boon Wee Teo,
  • Breana Cham,
  • Celeste Jia Ying Yap,
  • Cynthia Ciwei Lim,
  • David Lu,
  • Esther Huimin Leow,
  • Hui-Lin Chin,
  • Jason C. J. Choo,
  • Ru Sin Lim,
  • Gek Cher Chan,
  • Yi Da,
  • Hui Kim Yap,
  • Irene Mok,
  • Jiin Ying Lim,
  • Jing Yi Ho,
  • Sharon Teo,
  • Perry Lau,
  • Hui Zhuan Tan,
  • Tung Lin Lee,
  • Yong Hong Ng,
  • Indra Ganesan,
  • Siew Le Chong,
  • Sing Ming Chao,
  • Jeannette Goh,
  • Jia Liang Kwek,
  • Jun Li Ng,
  • Kay Yuan Chong,
  • Mya Than,
  • Naline Gandhi,
  • Regina Shaoying Lim,
  • See Cheng Yeo,
  • Su Mein Goh,
  • Sylvia Kam,
  • Yaochun Zhang,
  • Ziyin Wang,
  • Chi Hui Chin,
  • Desmond Luan Seng Ong,
  • Han Boon Oh,
  • Peh Joo Ho,
  • Philip Choong Tsau Iau,
  • Pooja Jagmohan,
  • Sing Cheer Kwek,
  • Su-Ann Goh,
  • Sujith Wijerathne,
  • Zhi Peng Zhang,
  • Chester Drum,
  • Eric Tien Siang Lim,
  • Fabian Yap,
  • Fathima Ashna Nastar,
  • Hong Chang Tan,
  • Ian Jan Ming Koh,
  • Ju Le Tan,
  • Konstadina Griva,
  • Natalie Si Ya Koh,
  • Quek Wei Yeong,
  • Rinkoo Dalan,
  • Sanjaya Dissanayake,
  • Terrence Chua,
  • Wann Jia Loh,
  • Yee Sian Tiong,
  • Amanda Lay Ying Lim,
  • Benjamin Yong-Qiang Tan,
  • Christina Jiun Yu Tan,
  • Dennis Chua,
  • Evelyn Shi Jie Tan,
  • Golda Wang,
  • Huang En Toh,
  • Hui Min Chua,
  • Jared D’Souza,
  • Jing Wen Oh,
  • Jishana Farhad,
  • Kaavya Narasimhalu,
  • Kee Yuan Ngiam,
  • Ken Juin Lim,
  • Khai Pang Leong,
  • Liuh Ling Goh,
  • Min Yi Gwee,
  • Pei Shieen Wong,
  • Rangpa Taiju,
  • Siok Ying Lee,
  • Teck Choon Tan,
  • Yi Min Wan,
  • Zewen Zhang,
  • Eleanor Wong,
  • Kriti Sethi,
  • Doreen Low,
  • Irenaeus Paul Chia,
  • Yasmin Bylstra,
  • Weng Khong Lim,
  • Saumya Jamuar,
  • Ruifen Weng,
  • Marthe Smedinga,
  • Tamra Lysaght,
  • Weiling Zheng,
  • Mingshi Koh,
  • Jimmy Lee,
  • Sabrina Wong,
  • Khung Keong Yeo,
  • Ching-Yu Cheng,
  • Charumathi Sabanayagam,
  • Xueling Sim,
  • Boon Cher Goh,
  • Chiea Chuen Khor,
  • Nicolas Bertin,
  • Ee Shien Tan,
  • Max Lam,
  • E. Shyong Tai,
  • John Chambers,
  • Patrick Tan

摘要

The Singapore National Precision Medicine (NPM) program is a three-phase whole-of-nation effort designed to develop scalable, evidence-based solutions for precision health tailored to Asia’s diverse populations. Here we present NPM phase II (2020–2025), highlighting how large-scale precision medicine initiatives can drive new research insights, enable healthcare innovations and create economic value. Key achievements include the PRECISE-SG100K population dataset, which reflects Singapore’s unique multi-ancestry Asian population; the successful translation of research findings into mainstream national healthcare using familial hypercholesterolemia as a use case; and the establishment of strategic public–private partnerships with diverse industry sectors. We also outline phase III (2025–2031), which aims to establish whole-genome sequencing as a foundational element of a patient’s lifelong healthcare record for 10% of the population. NPM provides a model for how smaller countries, despite limited populations and finite resources, can contribute meaningfully to global scientific movements while preserving strategic independence and addressing national health challenges.