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<p>Cytosine base editors (CBEs) show promise for multiplex gene knockout applications, but impure edits, indels and off-targets still frequently occur. We describe here QBEmax, which exhibits high efficiency, low indel and off-targets and high product purity with up to 99.8% of edits comprised of C-to-T. Through molecular dynamic modeling, QBEmax presents as a compact and stable base editor that shields protected bases from undesired repair processes.</p>

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QBEmax is a sequence-permuted and internally protected base editor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月21日

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  • Jiacheng Hu,
  • Mengyue Guo,
  • Qiang Gao,
  • He Jia,
  • Mingyang He,
  • Zhiwei Wang,
  • Lina Guo,
  • Guanwen Liu,
  • Quan Gao,
  • Kevin Tianmeng Zhao

摘要

Cytosine base editors (CBEs) show promise for multiplex gene knockout applications, but impure edits, indels and off-targets still frequently occur. We describe here QBEmax, which exhibits high efficiency, low indel and off-targets and high product purity with up to 99.8% of edits comprised of C-to-T. Through molecular dynamic modeling, QBEmax presents as a compact and stable base editor that shields protected bases from undesired repair processes.