<p>Monitoring internal physiological signals is essential for effective medical care<sup><CitationRef CitationID="CR1">1</CitationRef></sup>, yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics<sup><CitationRef AdditionalCitationIDS="CR3 CR4 CR5" CitationID="CR2">2</CitationRef>–<CitationRef CitationID="CR6">6</CitationRef></sup>. Implantable devices offer a solution, but conventional designs often require batteries or magnets<sup><CitationRef AdditionalCitationIDS="CR8 CR9 CR10" CitationID="CR7">7</CitationRef>–<CitationRef CitationID="CR11">11</CitationRef></sup>, which carry risks during removal, and existing biodegradable sensors based on passive inductor–capacitor circuits&#xa0;are limited by short readout distances and unstable communication issues<sup><CitationRef AdditionalCitationIDS="CR13 CR14 CR15 CR16 CR17 CR18" CitationID="CR12">12</CitationRef>–<CitationRef CitationID="CR19">19</CitationRef></sup>. Here we describe a soft, biodegradable, wireless sensing device that can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles. This is achieved through a ‘pole-moving sweeping’ readout system combined with a folded structure that integrates mechanical flexibility with electromagnetic function. In vivo tests in the abdominal cavity of horses reliably captured deep-tissue pressure and temperature, and ex vivo measurements demonstrated accurate strain monitoring without strict positional control. The long-distance and wide-angle readout of soft biodegradable implants holds translational promise for accessing deep-tissue physiological signals.</p>

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Soft biodegradable implants for long-distance and wide-angle sensing

  • Yuqun Lan,
  • Shuang Li,
  • Haitao Guo,
  • Qinyuan Liu,
  • Tairan Wang,
  • Lianqiao Zhou,
  • Jiahuiyu Fang,
  • Yang Zhao,
  • Zanxin Zhou,
  • Qi Wang,
  • Jing Li,
  • Yiping Zhu,
  • Rongfang Su,
  • Xinyi Wen,
  • Xinkai Xu,
  • Yuhong Wu,
  • Zixuan Wang,
  • Bo Liu,
  • Jiaqi Li,
  • Hui Li,
  • Hanfei Gao,
  • Yuchen Wu,
  • Qi Gu,
  • Xi-Qiao Feng,
  • Xinge Yu,
  • Yewang Su

摘要

Monitoring internal physiological signals is essential for effective medical care1, yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics26. Implantable devices offer a solution, but conventional designs often require batteries or magnets711, which carry risks during removal, and existing biodegradable sensors based on passive inductor–capacitor circuits are limited by short readout distances and unstable communication issues1219. Here we describe a soft, biodegradable, wireless sensing device that can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles. This is achieved through a ‘pole-moving sweeping’ readout system combined with a folded structure that integrates mechanical flexibility with electromagnetic function. In vivo tests in the abdominal cavity of horses reliably captured deep-tissue pressure and temperature, and ex vivo measurements demonstrated accurate strain monitoring without strict positional control. The long-distance and wide-angle readout of soft biodegradable implants holds translational promise for accessing deep-tissue physiological signals.