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<p>Regulatory T (T<sub>reg</sub>) cells have a central role in the maintenance of immune surveillance and tolerance. They can migrate from lymphoid organs to blood and then into tissues and egress from tissues into draining lymph nodes. Specialized endothelial cells of blood and lymphatic vessels are the key gatekeepers for these processes. T<sub>reg</sub> cells that transmigrate across single-cell layers of endothelial cells engage in bidirectional crosstalk with these cells and regulate vascular permeability by promoting structural modifications of blood and lymphatic endothelial cells. In turn, blood and lymphatic endothelial cells can modulate T<sub>reg</sub> cell recirculation and residency. Here, we discuss recent insights into the cellular and molecular mechanisms of the crosstalk between T<sub>reg</sub> cells and endothelial cells and explore potential therapeutic strategies to target these interactions in autoimmunity, transplantation and cancer.</p>

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Regulatory T cell and endothelial cell crosstalk

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Wenji Piao,
  • Zachariah L. Lee,
  • Gregory Zapas,
  • Long Wu,
  • Christopher M. Jewell,
  • Reza Abdi,
  • Jonathan S. Bromberg

摘要

Regulatory T (Treg) cells have a central role in the maintenance of immune surveillance and tolerance. They can migrate from lymphoid organs to blood and then into tissues and egress from tissues into draining lymph nodes. Specialized endothelial cells of blood and lymphatic vessels are the key gatekeepers for these processes. Treg cells that transmigrate across single-cell layers of endothelial cells engage in bidirectional crosstalk with these cells and regulate vascular permeability by promoting structural modifications of blood and lymphatic endothelial cells. In turn, blood and lymphatic endothelial cells can modulate Treg cell recirculation and residency. Here, we discuss recent insights into the cellular and molecular mechanisms of the crosstalk between Treg cells and endothelial cells and explore potential therapeutic strategies to target these interactions in autoimmunity, transplantation and cancer.