Scholarlink

<p>The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a crucial component of the innate immune system, having important roles in antimicrobial defence, inflammatory disease, ageing, autoimmunity and cancer. Recent work suggests that the regulation of cGAS–STING signalling is complex and sophisticated. In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we discuss how the cGAS–STING pathway is regulated by both activating and inhibitory factors. Furthermore, we summarize the newly emerging understanding of crosstalk between cGAS–STING signalling and other signalling pathways and provide examples to highlight the wide variety of cellular processes in which cGAS–STING signalling is involved, including autophagy, metabolism, ageing, inflammation and tumorigenesis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulation of cGAS–STING signalling and its diversity of cellular outcomes

  • 期刊论文

  • 发表日期：

    2025年1月7日

查看全文
  • Zhengyin Zhang,
  • Conggang Zhang

摘要

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a crucial component of the innate immune system, having important roles in antimicrobial defence, inflammatory disease, ageing, autoimmunity and cancer. Recent work suggests that the regulation of cGAS–STING signalling is complex and sophisticated. In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we discuss how the cGAS–STING pathway is regulated by both activating and inhibitory factors. Furthermore, we summarize the newly emerging understanding of crosstalk between cGAS–STING signalling and other signalling pathways and provide examples to highlight the wide variety of cellular processes in which cGAS–STING signalling is involved, including autophagy, metabolism, ageing, inflammation and tumorigenesis.