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<p>The human microbiome is a complex ecosystem of microorganisms that inhabit the human body and have a crucial role in human health. Microbiome composition is shaped by its interaction with many factors, including human genetics. Advances in genomic technologies are improving the ability to quantify the effect of human genetics on the microbiome through improved heritability studies and microbiome genome-wide association studies (GWAS). Complementary studies using transcriptomic analyses are providing a more comprehensive view of the bidirectional relationship between host gene expression and the microbiome. The resulting insights into the genetic mechanisms driving host–microbiome interactions will ultimately contribute to the development of personalized medicine and targeted therapies.</p>

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Genomics of host–microbiome interactions in humans

  • 期刊论文

  • 发表日期：

    2025年6月4日

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  • Pamela Ferretti,
  • Kelsey Johnson,
  • Sambhawa Priya,
  • Ran Blekhman

摘要

The human microbiome is a complex ecosystem of microorganisms that inhabit the human body and have a crucial role in human health. Microbiome composition is shaped by its interaction with many factors, including human genetics. Advances in genomic technologies are improving the ability to quantify the effect of human genetics on the microbiome through improved heritability studies and microbiome genome-wide association studies (GWAS). Complementary studies using transcriptomic analyses are providing a more comprehensive view of the bidirectional relationship between host gene expression and the microbiome. The resulting insights into the genetic mechanisms driving host–microbiome interactions will ultimately contribute to the development of personalized medicine and targeted therapies.