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<p>Intrapancreatic fat deposition (IPFD) has garnered appreciable attention across diverse medical disciplines amid the rising global burden of pancreatitis, pancreatic cancer and type 2 diabetes mellitus. Despite growing interest in the field, there remains no conceptual framework for it. To address this gap, 25 experts from 6 continents were brought together to develop guidance. Drawing on multiple peer-reviewed systematic reviews and applying an iterative, anonymous Delphi process, a consensus document was developed and ratified in Melbourne, Australia. The final document contains 58 recommendations — 30 reached unanimous agreement and 28 attained 90–99% agreement. The consensus formally defines fatty pancreas disorder (FPD) as a distinct pathological state, characterized by excessive IPFD that poses a risk to health. Assessment of IPFD is best performed with MRI. Expert-established diagnostic criteria enable identification and classification of FPD. Recognition of type 1 FPD (in individuals without excess body fat mass) and type 2 FPD (in individuals with excess body fat mass) is instrumental in gaining novel insights and tailoring preventive strategies to the individual. The Melbourne consensus is foundational in operationalizing the dissemination of new knowledge in the field, fostering intercontinental collaborations and, ultimately, addressing the global burden of diseases of the pancreas.</p>

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Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus

  • 期刊论文

  • 发表日期：

    2026年7月16日

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  • Maxim S. Petrov,
  • Hajime Yamazaki,
  • Guotao Lu,
  • Ahmad H. Al-Mrabeh,
  • Claudio Luchini,
  • Xiaowu Dong,
  • Tsuyoshi Hamada,
  • Yutong Liu,
  • Hiroki Oyama,
  • Susanne Rospleszcz,
  • Saurabh Chawla,
  • Yan Shen,
  • Ethem Turgay Cerit,
  • Idoia Labayen,
  • John Virostko,
  • Tuo Li,
  • Cristina Cadenas-Sanchez,
  • Laure Alexandre-Heymann,
  • Reda Albadawy,
  • Danijela Budimir Mršić,
  • Giuseppe Della Pepa,
  • Zhiyin Huang,
  • Juyeon Ko,
  • Xiaoyu Li,
  • Sunitha Priya,
  • Matheus Souza,
  • José Celso Ardengh,
  • Mohamed Bilal Azam,
  • Akif Bayyigit,
  • Michele Bevere,
  • Sakina H. Bharmal,
  • Faraz Bishehsari,
  • Roberto Bizzotto,
  • Federico Caldart,
  • James Cantley,
  • Feng Cao,
  • Udit Chauhan,
  • Guozhong Chen,
  • Ning Chen,
  • Song Chen,
  • Weigang Chen,
  • Weiwei Chen,
  • Sudipta Dhar Chowdhury,
  • Nicolò De Pretis,
  • Viviane Delghingaro-Augusto,
  • Lihui Deng,
  • Marcio Garrison Dytz,
  • Bara El Kurdi,
  • Amany A. Elbanna,
  • Spiros Fourlanos,
  • Gema Frühbeck,
  • Louise M. Goff,
  • Jorge Carvalho Guedes,
  • Vishal Gupta,
  • Nadia M. Hamdy,
  • Chaoqun Han,
  • Jianyu Hao,
  • Ahmed Morad Hashim,
  • Wenhua He,
  • Guoyong Hu,
  • Lianghao Hu,
  • Brian Z. Huang,
  • Haojie Huang,
  • Heguang Huang,
  • Wei Huang,
  • Bei Ji,
  • Meng Jin,
  • Tej Joshi,
  • Mehmet Kanbay,
  • Ryul Kang,
  • Shanlin Ke,
  • Julia S. Kenkre,
  • Lauren Khanna,
  • Tawfik Khoury,
  • Sarah Kilian,
  • Niwen Kong,
  • Xiangyu Kong,
  • Bedriye Koyuncu Sokmen,
  • Junji Kozawa,
  • Mohammad Shafi Kuchay,
  • Naotaka Kugiyama,
  • Chani-Brynn Leybourne,
  • Chengpeng Li,
  • Guichen Li,
  • Jing Li,
  • Xinye Li,
  • Weiqin Li,
  • Hai Lin,
  • Xinjuan Liu,
  • Zhilan Liu,
  • Jiajie Lu,
  • Zipeng Lu,
  • Chao Luo,
  • Ke Lv,
  • Ying Lv,
  • Eva Marín-Serrano,
  • David Marti-Aguado,
  • Teresa L. Mastracci,
  • Marwa Matboli,
  • Paola Mattiolo,
  • Bruno Pereira Melo,
  • Jiarong Miao,
  • Anoop Misra,
  • Yousuke Nakai,
  • Hussein Hassan Okasha,
  • Claudia P. Oliveira,
  • Aysegul Oz,
  • Osman Özdoğan,
  • Nonthalee Pausawasdi,
  • Jie Peng,
  • Shanta J. Persaud,
  • Joanna M. Pienkowska,
  • Tingyue Qi,
  • Weiguang Qiao,
  • Yi Qin,
  • Ramesh Rajan,
  • Hongbo Ren,
  • Takahiko Sakaue,
  • Sara A. Sedeek,
  • Gabriel Q. Shaibi,
  • Xiatiguli Shamaitijiang,
  • Dong Shang,
  • Qiao Shi,
  • Xiaolei Shi,
  • Shuhei Shinoda,
  • Channabasappa Shivaprasad,
  • Loren Skudder-Hill,
  • Samantha A. Streicher,
  • Charlotte Stuart,
  • Tricia M-M Tan,
  • Raymond Shing Yan Tang,
  • Xiaowei Tang,
  • Pengxian Tao,
  • Ahmed Tawheed,
  • E. Louise Thomas,
  • Andrew T. Trout,
  • Fatih Türker,
  • Nicola Veronese,
  • Cristiane A. Villela-Nogueira,
  • Alexander von Kriegsheim,
  • Meihua Wan,
  • Rong Wan,
  • Gang Wang,
  • Shengfeng Wang,
  • Wei Wang,
  • Yaochen Wang,
  • Zheng Wang,
  • Wenping Wei,
  • Li Wen,
  • Dong Wu,
  • Heshui Wu,
  • Wenbin Wu,
  • Katie Wynne,
  • Liang Xia,
  • Hong Xiang,
  • Hongwei Xu,
  • Kedong Xu,
  • Qiang Xu,
  • Hanieh Yaghootkar,
  • Yong Yang,
  • Cemal Yazici,
  • Tao Yin,
  • Ping Yu,
  • Xiao Yu,
  • Xiaoping Yu,
  • Chenchen Yuan,
  • Yue Zeng,
  • Wenlong Zhai,
  • Jasmine Zhang,
  • Xiaofeng Zhang,
  • Yao Zhang,
  • Yingxin Zhang,
  • Yun Zhang,
  • Yi Zhao,
  • Chunhua Zhou,
  • Sisi Zhou,
  • Changju Zhu,
  • Kexiang Zhu,
  • Qingtian Zhu,
  • Xiaoliang Zhu,
  • Yin Zhu,
  • Duowu Zou,
  • Wenbin Zou

摘要

Intrapancreatic fat deposition (IPFD) has garnered appreciable attention across diverse medical disciplines amid the rising global burden of pancreatitis, pancreatic cancer and type 2 diabetes mellitus. Despite growing interest in the field, there remains no conceptual framework for it. To address this gap, 25 experts from 6 continents were brought together to develop guidance. Drawing on multiple peer-reviewed systematic reviews and applying an iterative, anonymous Delphi process, a consensus document was developed and ratified in Melbourne, Australia. The final document contains 58 recommendations — 30 reached unanimous agreement and 28 attained 90–99% agreement. The consensus formally defines fatty pancreas disorder (FPD) as a distinct pathological state, characterized by excessive IPFD that poses a risk to health. Assessment of IPFD is best performed with MRI. Expert-established diagnostic criteria enable identification and classification of FPD. Recognition of type 1 FPD (in individuals without excess body fat mass) and type 2 FPD (in individuals with excess body fat mass) is instrumental in gaining novel insights and tailoring preventive strategies to the individual. The Melbourne consensus is foundational in operationalizing the dissemination of new knowledge in the field, fostering intercontinental collaborations and, ultimately, addressing the global burden of diseases of the pancreas.