<p>Non-Hermitian physics has recently transformed our understanding of topology by uncovering a range of effects that are unique to systems with gain and loss. The realization of non-Hermitian topology in strongly coupled light–matter systems not only offers degrees of freedom for the enhanced manipulation of topological phenomena, but is also promising for developing on-chip active photonic devices. Exciton–polaritons—strongly coupled quasiparticles from excitons and photons—emerge as a promising candidate with intrinsic non-Hermitian features. However, limited by the challenges in achieving non-reciprocity, the experimental observation of non-Hermitian topology and its associated transport features has remained elusive. Here we experimentally demonstrate the non-Hermitian topology of exciton–polaritons induced by a twist degree of freedom in a liquid-crystal-filled CsPbBr₃ perovskite microcavity at room temperature. The geometric twist between birefringent perovskites and liquid crystals acts as a degree of freedom to tailor the polaritonic complex spectra, leading to non-Hermitian bands with spectral winding topology and non-reciprocity. Furthermore, the induced non-Hermitian topology gives rise to the non-Hermitian exciton–polariton skin effect in real space, manifesting as polariton accumulation at open boundaries. Our findings open new perspectives on tunable non-Hermitian phenomena and the development of on-chip polaritonic devices with enhanced functionalities.</p>