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<p>For nanoscale X-ray imaging, scanning-based techniques are widely used, but the scanning process often becomes a bottleneck for measurement speed. Scanless, single-shot imaging provides a promising approach to drastically reduce acquisition time. However, achieving both a large field of view and high spatial resolution without scanning remains a significant challenge. Here we show single-shot in-line holography for femtosecond imaging with a field of view exceeding 1 µm and a spatial resolution of 10 nm, using X-ray free-electron laser pulses. This was achieved by combining two key approaches: advanced mirror optics to generate a sub-10-nm focal spot and an algorithm to compensate for fluctuations in illumination caused by the stochastic nature of the self-amplified spontaneous emission free-electron laser process. This method provides a new strategy to fully exploit the brilliance of state-of-the-art X-ray sources for advanced imaging.</p>

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Single-shot full-field X-ray imaging with 10-nm resolution using hard X-ray free-electron laser pulses

  • 期刊论文

  • 发表日期：

    2026年6月3日

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  • Gota Yamaguchi,
  • Jumpei Yamada,
  • Kota Shioi,
  • Taito Osaka,
  • Ichiro Inoue,
  • Yuichi Inubushi,
  • Takashi Kameshima,
  • Kazuto Yamauchi,
  • Makina Yabashi

摘要

For nanoscale X-ray imaging, scanning-based techniques are widely used, but the scanning process often becomes a bottleneck for measurement speed. Scanless, single-shot imaging provides a promising approach to drastically reduce acquisition time. However, achieving both a large field of view and high spatial resolution without scanning remains a significant challenge. Here we show single-shot in-line holography for femtosecond imaging with a field of view exceeding 1 µm and a spatial resolution of 10 nm, using X-ray free-electron laser pulses. This was achieved by combining two key approaches: advanced mirror optics to generate a sub-10-nm focal spot and an algorithm to compensate for fluctuations in illumination caused by the stochastic nature of the self-amplified spontaneous emission free-electron laser process. This method provides a new strategy to fully exploit the brilliance of state-of-the-art X-ray sources for advanced imaging.