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<p>Recurrent urinary tract infections are recalcitrant and difficult-to-treat bacterial infections that primarily affect women. Here we combine phage therapy with faecal microbiota transplantation to decolonize the urinary and intestinal reservoirs of patients with recurrent urinary tract infections. Three women received oral and intravesical phage therapy for 8 days, and two underwent subsequent faecal microbiota transplantation. Treatments were well tolerated, and although <i>Escherichia coli</i> was detected in follow-up samples, patients experienced none or fewer and less severe episodes of urinary tract infection 24 months post-treatment.</p>

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Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月30日

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  • Shawna McCallin,
  • Annika Y. Classen,
  • Simone C. Lieberknecht-Jouy,
  • Fatih Abdula,
  • Sarah Dugas,
  • Oliver Gross,
  • Hendrik Koliwer-Brandl,
  • Swenja Lassen,
  • Jens Scheidegger,
  • Matthew Dunne,
  • Andre Kahles,
  • Jonas Eigler,
  • Fedja Farowski,
  • Paul G. Higgins,
  • Sonja Milek,
  • Oksana Chemych,
  • Jiemin Du,
  • Martin J. Loessner,
  • Thomas M. Kessler,
  • Maria J. G. T. Vehreschild,
  • Lorenz Leitner,
  • Lena M. Biehl

摘要

Recurrent urinary tract infections are recalcitrant and difficult-to-treat bacterial infections that primarily affect women. Here we combine phage therapy with faecal microbiota transplantation to decolonize the urinary and intestinal reservoirs of patients with recurrent urinary tract infections. Three women received oral and intravesical phage therapy for 8 days, and two underwent subsequent faecal microbiota transplantation. Treatments were well tolerated, and although Escherichia coli was detected in follow-up samples, patients experienced none or fewer and less severe episodes of urinary tract infection 24 months post-treatment.