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<p>Only few cases of human immunodeficiency virus (HIV) remission have been reported after allogeneic haematopoietic stem cell transplantation (HSCT), mostly involving stem cell donors with the homozygous <i>CCR5</i>Δ32 (<i>CCR5</i>Δ32/Δ32) mutation, which confers resistance to CCR5-tropic HIV-1. Here we report the case of a 63-year-old man in off-treatment HIV remission, 5 years after HSCT with a <i>CCR5</i>Δ32/Δ32 sibling donor for myelodysplastic syndrome. In-depth clinical characterization including virological and immunological analyses of peripheral blood, gut and bone marrow samples revealed that full donor chimerism was achieved. Antiretroviral therapy was discontinued after 24 months, and 48 months after HSCT, no intact HIV DNA was detected in blood or gut biopsies. Replication-competent virus and HIV-specific T cell responses were absent, and HIV antibody responses showed a gradual decline. Full donor chimerism in the gut, which is the primary viral reservoir, underscores the likelihood of a cure.</p>

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Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor

  • 期刊论文

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  • 发表日期：

    2026年4月13日

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  • Anders Eivind Myhre,
  • Malin Holm Meyer-Myklestad,
  • Hanne Hestdal Gullaksen,
  • Ole S. Søgaard,
  • Martin Tolstrup,
  • Maria Salgado,
  • Javier Martinez-Picado,
  • Mona Holberg-Petersen,
  • Anna Karina Juhl,
  • Mariane H. Schleimann,
  • Jesper D. Gunst,
  • Astrid Thomsen,
  • Katie Fisher,
  • Jagjit Singh Bhamra,
  • Anne-Marte Bakken Kran,
  • Bente Halvorsen,
  • Anne Ma Dyrhol-Riise,
  • Dag Henrik Reikvam,
  • Pål Aukrust,
  • Tobias Gedde-Dahl,
  • Hans Christian D. Aass,
  • Pål Aukrust,
  • Anne Marte Bakken-Kran,
  • Jagiit S. Bhamra,
  • Magnar Bjørås,
  • Tuva B. Dahl,
  • Anne Ma Dyrhol-Riise,
  • Tobias Gedde-Dahl,
  • Hanne Guldsten,
  • Hanne H. Gullaksen,
  • Bente Halvorsen,
  • Mona Holberg-Petersen,
  • Marte L. Høivik,
  • Frode L. Jahnsen,
  • Mari Kaarbø,
  • Andreas Lind,
  • Gunilla Løvgården,
  • Asle W. Medhus,
  • Malin H. Meyer-Myklestad,
  • Fredrik Müller,
  • Anders E. Myhre,
  • Sarah Nur,
  • Azita Rashidi,
  • Dag Henrik Reikvam,
  • Marius Trøseid,
  • Magnus Moksnes,
  • Katie Fisher,
  • Jesper D. Gunst,
  • Anna Karina Juhl,
  • Mariane H. Schleimann,
  • Ole Søgaard,
  • Astrid Thomsen,
  • Martin Tolstrup,
  • Gerard Campos,
  • Gema Fernández Rivas,
  • Maria del Carmen García Guerrero,
  • Irene González Navarro,
  • Victoria González Soler,
  • Águeda Hernández,
  • Javier Martinez-Picado,
  • Maria Salgado,
  • Piotr Nowak,
  • Anders Sönnerborg,
  • Tuva Børresdatter Dahl,
  • Mari Kaarbø,
  • Marius Trøseid

摘要

Only few cases of human immunodeficiency virus (HIV) remission have been reported after allogeneic haematopoietic stem cell transplantation (HSCT), mostly involving stem cell donors with the homozygous CCR5Δ32 (CCR5Δ32/Δ32) mutation, which confers resistance to CCR5-tropic HIV-1. Here we report the case of a 63-year-old man in off-treatment HIV remission, 5 years after HSCT with a CCR5Δ32/Δ32 sibling donor for myelodysplastic syndrome. In-depth clinical characterization including virological and immunological analyses of peripheral blood, gut and bone marrow samples revealed that full donor chimerism was achieved. Antiretroviral therapy was discontinued after 24 months, and 48 months after HSCT, no intact HIV DNA was detected in blood or gut biopsies. Replication-competent virus and HIV-specific T cell responses were absent, and HIV antibody responses showed a gradual decline. Full donor chimerism in the gut, which is the primary viral reservoir, underscores the likelihood of a cure.