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<p>Bacterial polysaccharide capsules contribute to antigenic diversity and immune evasion. <i>Escherichia coli</i> infections, including those caused by extraintestinal pathogenic <i>E. coli</i> (ExPEC), cause substantial antimicrobial resistance-associated morbidity and mortality. However, much-needed genotypic methods for <i>E. coli</i> capsule typing to aid epidemiological analysis and therapeutic design are lacking. Here we describe the curation of an in silico typing database for group 2 and 3 ATP-binding cassette transporter-dependent capsule (K) loci from 18,185 <i>kps</i>-positive <i>E. coli</i> genomes from all continents and its application to carriage and ExPEC disease cohorts. Capsules K1, K5 and K2 were the most common types in European BSIs, and together with K100 and K52 they were responsible for 58% of multidrug resistance, with differing associations with invasiveness. Homologous recombination, insertion sequences and plasmids were associated with capsular gene exchange. These findings improve understanding of capsule epidemiology and evolution to inform future diagnostic and therapeutic strategies to combat ExPEC infections.</p>

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Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月25日

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  • Rebecca A. Gladstone,
  • Maiju Pesonen,
  • Anna K. Pöntinen,
  • Tommi Mäklin,
  • Neil MacAlasdair,
  • Harry Thorpe,
  • Yan Shao,
  • Sudaraka Mallawaarachchi,
  • Sergio Arredondo-Alonso,
  • Benjamin J. Parcell,
  • Jake David Turnbull,
  • Gerry Tonkin-hill,
  • Pål J. Johnsen,
  • Ørjan Samuelsen,
  • Nicholas R. Thomson,
  • Trevor Lawley,
  • Jukka Corander

摘要

Bacterial polysaccharide capsules contribute to antigenic diversity and immune evasion. Escherichia coli infections, including those caused by extraintestinal pathogenic E. coli (ExPEC), cause substantial antimicrobial resistance-associated morbidity and mortality. However, much-needed genotypic methods for E. coli capsule typing to aid epidemiological analysis and therapeutic design are lacking. Here we describe the curation of an in silico typing database for group 2 and 3 ATP-binding cassette transporter-dependent capsule (K) loci from 18,185 kps-positive E. coli genomes from all continents and its application to carriage and ExPEC disease cohorts. Capsules K1, K5 and K2 were the most common types in European BSIs, and together with K100 and K52 they were responsible for 58% of multidrug resistance, with differing associations with invasiveness. Homologous recombination, insertion sequences and plasmids were associated with capsular gene exchange. These findings improve understanding of capsule epidemiology and evolution to inform future diagnostic and therapeutic strategies to combat ExPEC infections.