Scholarlink

<p>Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironments is not fully understood. Here we report that the deformability of CTCs affects their haematogenous dissemination and identify mechanical phenotypes that favour metastatic extravasation. Combining intravital microscopy with CTC-mimicking elastic beads, mechanical tuning in tumour lines and profiling of tumour-patient-derived cells, we demonstrate that the inherent mechanical properties of circulating objects dictate their ability to enter constraining vessels. We identify cellular viscosity as a rheostat of CTC circulation and arrest, and show that cellular viscosity is crucial for efficient extravasation. Moreover, we find that mechanical properties that favour extravasation and subsequent metastatic outgrowth can be opposite. Altogether, our results establish CTC viscosity as a key biomechanical parameter that shapes several steps of metastasis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells

  • 期刊论文

  • 发表日期：

    2026年1月19日

查看全文
  • Valentin Gensbittel,
  • Zeynep Yesilata,
  • Louis Bochler,
  • Gautier Follain,
  • Laurie Nemoz-Billet,
  • Olivier Lefebvre,
  • Klemens Uhlmann,
  • Annabel Larnicol,
  • Giulia E. M. Ammirati,
  • Sébastien Harlepp,
  • Ruchi Goswami,
  • Salvatore Girardo,
  • Laetitia Paulen,
  • Vincent Hyenne,
  • Vincent Mittelheisser,
  • Tristan Stemmelen,
  • Anne Molitor,
  • Raphael Carapito,
  • Guillaume Belthier,
  • Julie Pannequin,
  • Martin Kräter,
  • Daniel J. Müller,
  • Daniel Balzani,
  • Jochen Guck,
  • Naël Osmani,
  • Jacky G. Goetz

摘要

Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironments is not fully understood. Here we report that the deformability of CTCs affects their haematogenous dissemination and identify mechanical phenotypes that favour metastatic extravasation. Combining intravital microscopy with CTC-mimicking elastic beads, mechanical tuning in tumour lines and profiling of tumour-patient-derived cells, we demonstrate that the inherent mechanical properties of circulating objects dictate their ability to enter constraining vessels. We identify cellular viscosity as a rheostat of CTC circulation and arrest, and show that cellular viscosity is crucial for efficient extravasation. Moreover, we find that mechanical properties that favour extravasation and subsequent metastatic outgrowth can be opposite. Altogether, our results establish CTC viscosity as a key biomechanical parameter that shapes several steps of metastasis.