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<p>Medical interventions often require timed series of doses, thus necessitating accurate medical record-keeping. In many global settings, these records are unreliable or unavailable at the point of care, leading to less effective treatments or disease prevention. Here we present an invisible-to-the-naked-eye on-patient medical record-keeping technology that accurately stores medical information in the patient skin as part of microneedles that are used for intradermal therapeutics. We optimize the microneedle design for both a reliable delivery of messenger RNA (mRNA) therapeutics and the near-infrared fluorescent microparticles that encode the on-patient medical record-keeping. Deep learning-based image processing enables encoding and decoding of the information with excellent temporal and spatial robustness. Long-term studies in a swine model demonstrate the safety, efficacy and reliability of this approach for the co-delivery of on-patient medical record-keeping and the mRNA vaccine encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This technology could help healthcare workers make informed decisions in circumstances where reliable record-keeping is unavailable, thus contributing to global healthcare equity.</p>

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On-patient medical record and mRNA therapeutics using intradermal microneedles

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月24日

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  • Jooli Han,
  • Maria Kanelli,
  • Yang Liu,
  • John L. Daristotle,
  • Apurva Pardeshi,
  • Timothy A. Forster,
  • Ari Karchin,
  • Brandon Folk,
  • Lukas Murmann,
  • Lisa H. Tostanoski,
  • Sebastian E. Carrasco,
  • Shahad K. Alsaiari,
  • Erika Yan Wang,
  • Khanh Tran,
  • Linzixuan Zhang,
  • Behnaz Eshaghi,
  • Lauren Levy,
  • Sydney Pyon,
  • Charles Sloane,
  • Stacey Qiaohui Lin,
  • Alicia Lau,
  • Collin F. Perkinson,
  • Moungi G. Bawendi,
  • Dan H. Barouch,
  • Frédo Durand,
  • Robert Langer,
  • Ana Jaklenec

摘要

Medical interventions often require timed series of doses, thus necessitating accurate medical record-keeping. In many global settings, these records are unreliable or unavailable at the point of care, leading to less effective treatments or disease prevention. Here we present an invisible-to-the-naked-eye on-patient medical record-keeping technology that accurately stores medical information in the patient skin as part of microneedles that are used for intradermal therapeutics. We optimize the microneedle design for both a reliable delivery of messenger RNA (mRNA) therapeutics and the near-infrared fluorescent microparticles that encode the on-patient medical record-keeping. Deep learning-based image processing enables encoding and decoding of the information with excellent temporal and spatial robustness. Long-term studies in a swine model demonstrate the safety, efficacy and reliability of this approach for the co-delivery of on-patient medical record-keeping and the mRNA vaccine encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This technology could help healthcare workers make informed decisions in circumstances where reliable record-keeping is unavailable, thus contributing to global healthcare equity.