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<p>Digital, self-guided, single-session interventions (SSIs) deliver structured psychological support within one interaction. Here we crowdsourced 66 diverse 10-min SSIs for depression and, with input from researchers and lived-experience experts, selected 11 for testing in a preregistered online randomized controlled trial (ClinicalTrials.gov ID: <a href="https://clinicaltrials.gov/study/NCT06856668">NCT06856668</a>). US adults (<i>N</i> = 7,505) experiencing elevated depressive symptoms were randomly assigned to 1 of the 11 crowdsourced SSIs, a validated behavioural activation SSI (active comparator) or a control condition without intervention content. Nearly all SSIs improved psychological outcomes immediately after completion (<i>d</i> ≤ 0.37). However, only two SSIs significantly reduced depression at 4-week follow-up (<i>d</i> = 0.14 and 0.15). Unexpectedly, completing an SSI made participants feel less confident and less interested in making changes to overcome depression at 4 weeks, on average (<i>d</i> = 0.05). Future work should aim to leverage SSIs’ immediate benefits to promote sustained behaviour change or service engagement.</p>

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A crowdsourced megastudy of 12 digital single-session interventions for depression in US adults

  • 期刊论文

  • 发表日期：

    2026年3月2日

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  • Benjamin T. Kaveladze,
  • Jan G. Voelkel,
  • Michael N. Stagnaro,
  • Mingjing Huang,
  • Amanda E. Smock,
  • Erin K. Sullivan,
  • Yao M. Xu,
  • Madison P. McCall,
  • Juan Pablo Zapata,
  • Syed Ishtiaque Ahmed,
  • Ananya Bhattacharjee,
  • Iva Georgieva,
  • Rosa Hernandez-Ramos,
  • Kenneth S. Huber,
  • Julia K. Jennings,
  • Arianna C. Kirk,
  • Robert S. M. Knowles,
  • Rachel Kornfield,
  • Monika Neff Lind,
  • Michelle Liu,
  • Michael A. Liut,
  • Alex T. Mariakakis,
  • Ali M. Mattu,
  • Adam P. McGuire,
  • Jonah Meyerhoff,
  • Alissa J. Mrazek,
  • Michael D. Mrazek,
  • David C. Mohr,
  • Robert R. Morris,
  • Christopher J. Mosunic,
  • Hana Nip,
  • Allen Olson-Urtecho,
  • Jessa R. Podell,
  • Dustyn S. Ransom,
  • Shireen L. Rizvi,
  • Matthew W. Southward,
  • Sarah Elizabeth Stoeckl,
  • Madison E. Taylor,
  • Amy R. Texter,
  • Calvin V. Tower,
  • Angelique N. Trotter,
  • Joseph J. Williams,
  • Katherine E. Wislocki,
  • Elijah J. Woodson,
  • John Protzko,
  • Lorenzo Lorenzo-Luaces,
  • Stephen M. Schueller,
  • Matthew K. Nock,
  • Jessica L. Schleider

摘要

Digital, self-guided, single-session interventions (SSIs) deliver structured psychological support within one interaction. Here we crowdsourced 66 diverse 10-min SSIs for depression and, with input from researchers and lived-experience experts, selected 11 for testing in a preregistered online randomized controlled trial (ClinicalTrials.gov ID: NCT06856668). US adults (N = 7,505) experiencing elevated depressive symptoms were randomly assigned to 1 of the 11 crowdsourced SSIs, a validated behavioural activation SSI (active comparator) or a control condition without intervention content. Nearly all SSIs improved psychological outcomes immediately after completion (d ≤ 0.37). However, only two SSIs significantly reduced depression at 4-week follow-up (d = 0.14 and 0.15). Unexpectedly, completing an SSI made participants feel less confident and less interested in making changes to overcome depression at 4 weeks, on average (d = 0.05). Future work should aim to leverage SSIs’ immediate benefits to promote sustained behaviour change or service engagement.