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<p>Highly ordered two-dimensional (2D) peptide structures were first proposed in 1975 as synthetic analogues of biological membranes, capable of mimicking the enantioselective recognition of biomolecules through atomically thin architectures. However, constructing ultrathin single-crystalline 2D peptide materials remains challenging because long-range ordered intralayer hydrogen-bonding networks are difficult to establish and maintain. Here we report a metal-directed β-sheet-like assembly strategy that affords 2D peptide crystals featuring parallel and antiparallel β-sheet organizations, with programmable control over sequence, chirality and side-chain chemistry. The antiparallel arrangement promotes intralayer mechanical interlocking, thereby enhancing the stability of the 2D lattice. Crystallographic analysis of diverse metal-peptide architectures reveals key structural determinants and elucidates the mechanism behind 2D interlocked assembly. These layered crystals can be exfoliated into free-standing, single-crystalline ultrathin nanosheets that stereoselectively bind glucocorticoids and chiral pharmaceutical molecules, with enantioselectivity up to 20.9. This work establishes a general strategy for creating structurally diverse 2D crystalline materials with tunable surfaces and programmable functions.</p><p></p>

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Free-standing ultrathin two-dimensional peptide crystals

  • 期刊论文

  • 发表日期：

    2026年6月1日

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  • Xiao Wang,
  • Rui Yao,
  • Shuai-Liang Yang,
  • Meng Jin,
  • Bingyu Liu,
  • Liang Qiao,
  • Xing Zhang,
  • Jie Liu,
  • Peijie Wu,
  • Luofei Wei,
  • Wenqiang Zhang,
  • Wei Gong,
  • Yan Liu,
  • Kecheng Cao,
  • Guozan Yuan,
  • Jinqiao Dong,
  • Yong Cui

摘要

Highly ordered two-dimensional (2D) peptide structures were first proposed in 1975 as synthetic analogues of biological membranes, capable of mimicking the enantioselective recognition of biomolecules through atomically thin architectures. However, constructing ultrathin single-crystalline 2D peptide materials remains challenging because long-range ordered intralayer hydrogen-bonding networks are difficult to establish and maintain. Here we report a metal-directed β-sheet-like assembly strategy that affords 2D peptide crystals featuring parallel and antiparallel β-sheet organizations, with programmable control over sequence, chirality and side-chain chemistry. The antiparallel arrangement promotes intralayer mechanical interlocking, thereby enhancing the stability of the 2D lattice. Crystallographic analysis of diverse metal-peptide architectures reveals key structural determinants and elucidates the mechanism behind 2D interlocked assembly. These layered crystals can be exfoliated into free-standing, single-crystalline ultrathin nanosheets that stereoselectively bind glucocorticoids and chiral pharmaceutical molecules, with enantioselectivity up to 20.9. This work establishes a general strategy for creating structurally diverse 2D crystalline materials with tunable surfaces and programmable functions.