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<p>The combined threats of future sarbecovirus zoonosis and continually emerging SARS-CoV-2 VOCs highlight the need to assess the breadth of existing SARS-CoV-2 vaccine-mediated protection. Here, we investigate a cohort of older individuals who received four COVID-19 vaccine doses, for potential cross-neutralisation against lentiviral particles bearing spikes from either Omicron VOCs or other sarbecoviruses. Despite recent fourth bivalent mRNA vaccine doses (encoding SARS-CoV-2 Wu-1 and Omicron spikes), neutralisation of Omicron lineage VOCs was reduced compared to Wu-1, consistent with an imprinted immune response. Similarly, particles bearing either SARS-CoV-1 or a SARS-CoV-1-related bat sarbecovirus spike were neutralised less efficiently than Wu-1. Unexpectedly, however, we observed that particles with spikes from two animal SARS-CoV-2-related viruses, BANAL-20-52 from bats and a pangolin CoV, were significantly more sensitive to serum neutralising antibodies than SARS-CoV-2 Wu-1 itself. These surprising findings suggest that vaccine-mediated adaptive immunity may provide efficient cross-neutralisation and potential protection against certain animal sarbecoviruses.</p>

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COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月1日

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  • Grace E. West,
  • Rebecca B. Morse,
  • Benjamin L. Sievers,
  • Adam Abdullahi,
  • Kimia Kamelian,
  • Mark Tsz Kin Cheng,
  • John R. Bradley,
  • Stephen Baker,
  • Barbara Graves,
  • Hannah Stark,
  • Sabine Hein,
  • Ingrid Scholtes,
  • Daniela Caputo,
  • Anne Elmer,
  • Emma Le Gresley,
  • Nathalie Kingston,
  • Patrick Chinnery,
  • Daniel Cooper,
  • Gordon Dougan,
  • Ian Goodfellow,
  • Nathalie Kingston,
  • Paul J. Lehner,
  • Paul A. Lyons,
  • Nicholas J. Matheson,
  • Caroline Saunders,
  • Kenneth G. C. Smith,
  • Charlotte Summers,
  • James Thaventhiran,
  • M. Estee Torok,
  • Mark R. Toshner,
  • Michael P. Weekes,
  • Gisele Alvio,
  • Sharon Baker,
  • Areti Bermperi,
  • Karen Brookes,
  • Isabel Cruz,
  • Ranalie de Jesus,
  • Katie Dempsey,
  • Giovanni Di Stephano,
  • Jason Domingo,
  • Sarah Hewitt,
  • Heather Jones,
  • Sherly Jose,
  • Jenny Kourampa,
  • Caroline McMahon,
  • Vivien Mendoza,
  • Charmain Ocaya,
  • Ciro Pasquale,
  • Marlyn Perales,
  • Carla Ribeiro,
  • Vargas,
  • Bensi Vergese,
  • Laura Watson,
  • Jieniean Worsley,
  • Julie-Ann Zerrudo,
  • Laura Bergamashi,
  • Gräf,
  • Kelvin Hunter,
  • Federica Mescia,
  • John Allison,
  • Heather Biggs,
  • Helen Butcher,
  • Matt Chandler,
  • Debbie Clapham-Riley,
  • Eleanor Dewhurst,
  • Christian Fernandez,
  • Anita Furlong,
  • Jennifer Gray,
  • Tasmin Ivers,
  • Rachel Linger,
  • Mary Kasanicki,
  • Rebecca King,
  • Sarah Meloy,
  • Alexei Moulton,
  • Francesca Muldoon,
  • Nigel Ovington,
  • Sofia Papadia,
  • Christopher J. Penkett,
  • Isabel Phelan,
  • Venkatesh Ranganath,
  • Roxana Paraschiv,
  • Abigail Sage,
  • Jennifer Sambrook,
  • Katherine Schon,
  • Kathleen E. Stirrups,
  • Paul Townsend,
  • Neil Walker,
  • Jennifer Webster,
  • Petra Polgarova,
  • Sarah L. Caddy,
  • Laura G. Caller,
  • Yasmin Chaudhry,
  • Martin D. Curran,
  • Theresa Feltwell,
  • Stewart Fuller,
  • Iliana Georgana,
  • Grant Hall,
  • William L. Hamilton,
  • Myra Hosmillo,
  • Charlotte J. Houldcroft,
  • Rhys Izuagbe,
  • Aminu S. Jahun,
  • Fahad A. Khokhar,
  • Anna G. Kovalenko,
  • Luke W. Meredith,
  • Surendra Parmar,
  • Malte L. Pinckert,
  • Anna Yakovleva,
  • Emily C. Horner,
  • Lucy Booth,
  • Alexander Ferreira,
  • Rebecca Boston,
  • Robert Hughes,
  • Juan Carlos Yam Puc,
  • Nonantzin Beristain-Covarrubias,
  • Maria Rust,
  • Thevinya Gurugama,
  • Lihinya Gurugama,
  • Thomas Mulroney,
  • Sarah Spencer,
  • Zhaleh Hosseini,
  • Kate Williamson,
  • Douglas G. Stewart,
  • Divya Diamond,
  • Mazharul Altaf,
  • Lourdes Ceron-Gutierrez,
  • Olga Sokolova,
  • David L. Robertson,
  • Spyros Lytras,
  • Rainer Döffinger,
  • Sam J. Wilson,
  • Suzannah J. Rihn,
  • Ravindra K. Gupta

摘要

The combined threats of future sarbecovirus zoonosis and continually emerging SARS-CoV-2 VOCs highlight the need to assess the breadth of existing SARS-CoV-2 vaccine-mediated protection. Here, we investigate a cohort of older individuals who received four COVID-19 vaccine doses, for potential cross-neutralisation against lentiviral particles bearing spikes from either Omicron VOCs or other sarbecoviruses. Despite recent fourth bivalent mRNA vaccine doses (encoding SARS-CoV-2 Wu-1 and Omicron spikes), neutralisation of Omicron lineage VOCs was reduced compared to Wu-1, consistent with an imprinted immune response. Similarly, particles bearing either SARS-CoV-1 or a SARS-CoV-1-related bat sarbecovirus spike were neutralised less efficiently than Wu-1. Unexpectedly, however, we observed that particles with spikes from two animal SARS-CoV-2-related viruses, BANAL-20-52 from bats and a pangolin CoV, were significantly more sensitive to serum neutralising antibodies than SARS-CoV-2 Wu-1 itself. These surprising findings suggest that vaccine-mediated adaptive immunity may provide efficient cross-neutralisation and potential protection against certain animal sarbecoviruses.