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<p>Taquet et al. evaluated the impact of AS01-adjuvanted vaccines on subsequent dementia diagnosis<sup><CitationRef CitationID="CR1">1</CitationRef></sup>. The authors conclude: “No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk”. Although the study offers promising evidence, the inference regarding the role of AS01 adjuvant in dementia prevention is not convincingly supported by the presented data or other published literature<sup><CitationRef CitationID="CR2">2</CitationRef></sup>.</p>

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Methodological Issues in Taquet et al.‘s analysis preclude any conclusions regarding AS01 adjuvant’s specific role in dementia prevention

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • S. Elizabeth Williams,
  • Kate Luisi,
  • Caihua Liang,
  • Alejandro Cane,
  • Elizabeth Begier

摘要

Taquet et al. evaluated the impact of AS01-adjuvanted vaccines on subsequent dementia diagnosis1. The authors conclude: “No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk”. Although the study offers promising evidence, the inference regarding the role of AS01 adjuvant in dementia prevention is not convincingly supported by the presented data or other published literature2.