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<p>Durable vaccine-induced immunity is the basis of long-term protection against infection and disease. This review covers three topics. First, we describe the immunological foundations of durable response and its determinants (e.g., vaccine design, host, and pathogen factors). Second, we summarize the current evidence regarding the durable immune responses conferred by mRNA- and adjuvanted protein-based vaccine platforms. Lastly, we discuss the challenges in developing durable mRNA vaccines and outline future considerations.</p>

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Establishing long-lasting vaccine immunity: insights from mRNA and adjuvanted protein platforms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月8日

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  • Andrea-Clemencia Pineda-Peña,
  • Kohei Hasegawa,
  • Vincent Pavot,
  • Catherine Berry,
  • Behazine Combadière,
  • Guadalupe Cortes-Garcia,
  • Adrian B. McDermott,
  • Saranya Sridhar

摘要

Durable vaccine-induced immunity is the basis of long-term protection against infection and disease. This review covers three topics. First, we describe the immunological foundations of durable response and its determinants (e.g., vaccine design, host, and pathogen factors). Second, we summarize the current evidence regarding the durable immune responses conferred by mRNA- and adjuvanted protein-based vaccine platforms. Lastly, we discuss the challenges in developing durable mRNA vaccines and outline future considerations.