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<p>Clinical progression and medium-long term morbidity from myocarditis following mRNA COVID-19 vaccinations remains an important but undefined public health concern. We conducted prospective follow-up of individuals with either confirmed or probable myocarditis following monovalent Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccination between 21 April 2021 and 5 July 2022 in Australia. Of 256 individuals who consented to follow up, mostly males following a second dose, 60% (133/221) had ongoing symptoms at 3-6 months and 35% (81/231) at 12-18 months. Self-reported ongoing exercise restrictions, medication requirements, and hospital re-presentations were associated with ongoing symptoms, as was a lower self-reported health status and quality of life. Clinical severity remained mild, with low hospitalisation rates and no deaths in the follow-up period and health-related quality of life improved over time. These findings support ongoing use of mRNA COVID-19 vaccines in at-risk individuals to prevent disease caused by SARS-CoV-2 infection.</p>

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Surveillance and follow up outcomes of myocarditis after mRNA COVID-19 vaccination in Australia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月16日

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  • Lucy Deng,
  • Amanda Van Eldik,
  • Megan O’Moore,
  • Jim Buttery,
  • Abigail Cheung,
  • Nicholas Cox,
  • Carla Drake-Brockman,
  • Nathan Dwyer,
  • Paul Effler,
  • Michael Gold,
  • Pravin Hissaria,
  • Andrew Kelly,
  • Sarah Khanlari,
  • Claire Larter,
  • Shannon Melody,
  • Michael Nissen,
  • Rajesh Puranik,
  • James Rankin,
  • Sally Singleton,
  • Liza Thomas,
  • Sudhir Wahi,
  • Gavin Wheaton,
  • Dominica Zentner,
  • Kristine Macartney,
  • Clara K. Chow,
  • Nicholas Wood

摘要

Clinical progression and medium-long term morbidity from myocarditis following mRNA COVID-19 vaccinations remains an important but undefined public health concern. We conducted prospective follow-up of individuals with either confirmed or probable myocarditis following monovalent Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccination between 21 April 2021 and 5 July 2022 in Australia. Of 256 individuals who consented to follow up, mostly males following a second dose, 60% (133/221) had ongoing symptoms at 3-6 months and 35% (81/231) at 12-18 months. Self-reported ongoing exercise restrictions, medication requirements, and hospital re-presentations were associated with ongoing symptoms, as was a lower self-reported health status and quality of life. Clinical severity remained mild, with low hospitalisation rates and no deaths in the follow-up period and health-related quality of life improved over time. These findings support ongoing use of mRNA COVID-19 vaccines in at-risk individuals to prevent disease caused by SARS-CoV-2 infection.