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<p>We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8<sup>+</sup> T-cell immunity, and provided protection against RSV A and B infection. These findings suggest that this vaccine combination holds promising potential for effective RSV prevention.</p>

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Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Eunju Jang,
  • Serin Lee,
  • Jiyu Han,
  • Jun Chang

摘要

We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8+ T-cell immunity, and provided protection against RSV A and B infection. These findings suggest that this vaccine combination holds promising potential for effective RSV prevention.