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<p>Solid-organ transplant (SOT) recipients are at enhanced risk of infection and to poorly respond to vaccination due to comorbidities and immunosuppression. We performed a systems vaccinology study in 59 kidney and 31 lung transplant recipients who received 3 doses of COVID-19 mRNA BNT162b2 vaccine. We were able to characterize a baseline configuration associated with an effective humoral response to 3 doses, characterized by an innate and activated B cell profile, whereas a T cell signature was associated with a poorer response. We observed a distinct configuration associated with a detectable humoral response to 2 doses, partly mediated by double negative B cell subsets. These results suggest that, despite their immunosuppression, some SOT recipients can induce an effective humoral response to 3 doses of vaccine supported by a baseline configuration close to the healthy phenotype. Baseline immune phenotyping may help identify SOT recipients at the greatest risk of a poor vaccine response.</p>

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Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Nicolas Gemander,
  • Julika Neumann,
  • Rafael Veiga,
  • Isabelle Etienne,
  • Teresa Prezzemolo,
  • Delphine Kemlin,
  • Pieter Pannus,
  • Stéphanie Depickère,
  • Véronique Olislagers,
  • Inès Vu Duc,
  • Alexandra Waegemans,
  • Margaux Gerbaux,
  • Leoni Bücken,
  • Hafid Dahma,
  • Charlotte Martin,
  • Nicolas Dauby,
  • Maria E. Goossens,
  • Isabelle Desombere,
  • Carlos P. Roca,
  • Mathijs Willemsen,
  • Stanislas Goriely,
  • Alain Le Moine,
  • Arnaud Marchant,
  • Adrian Liston,
  • Stephanie Humblet-Baron

摘要

Solid-organ transplant (SOT) recipients are at enhanced risk of infection and to poorly respond to vaccination due to comorbidities and immunosuppression. We performed a systems vaccinology study in 59 kidney and 31 lung transplant recipients who received 3 doses of COVID-19 mRNA BNT162b2 vaccine. We were able to characterize a baseline configuration associated with an effective humoral response to 3 doses, characterized by an innate and activated B cell profile, whereas a T cell signature was associated with a poorer response. We observed a distinct configuration associated with a detectable humoral response to 2 doses, partly mediated by double negative B cell subsets. These results suggest that, despite their immunosuppression, some SOT recipients can induce an effective humoral response to 3 doses of vaccine supported by a baseline configuration close to the healthy phenotype. Baseline immune phenotyping may help identify SOT recipients at the greatest risk of a poor vaccine response.