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<p>Pneumococcal vaccination is crucial in preventing <i>Streptococcus pneumoniae</i> infections in older adults. However, vaccine responses often diminish with age. This study investigates serotype-specific IgM and IgG responses in relation to opsonophagocytic activity (OPA) following thirteen-valent pneumococcal conjugate (PCV13) vaccination in younger (26–49 y; <i>n</i> = 44), middle-aged (50–64 y; <i>n</i> = 71), and older adults (65–98 y; <i>n</i> = 141). Both OPA and IgM responses declined with age, while IgG responses remained relatively stable. In younger adults, post-PCV13 OPA correlated moderate-to-strong with IgM for 8/13 serotypes and with IgG for only 4/13 serotypes. In contrast, middle-aged and older adults showed strong correlations between OPA and both IgM (10/13 serotypes) and IgG (12/13 serotypes). Overall, post-PCV13 OPA was predominantly associated with IgM levels. These observations suggest that declines in IgM, rather than IgG responses, explain reduced PCV13-induced opsonophagocytic activity in aging adults and may inform future vaccination strategies to enhance protection of older adults against pneumococcal disease.</p>

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Age-related decline in IgM responses associate with reduced opsonophagocytic activity following PCV13 vaccination

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月14日

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  • M. Visser,
  • J. van Beek,
  • I. Tcherniaeva,
  • D. M. van Rooijen,
  • L. Beckers,
  • E. Bijvank,
  • M. I. de Jonge,
  • S. P. Lockhart,
  • M. W. Pride,
  • N. Rots,
  • D. van Baarle,
  • G. den Hartog,
  • A. M. Buisman

摘要

Pneumococcal vaccination is crucial in preventing Streptococcus pneumoniae infections in older adults. However, vaccine responses often diminish with age. This study investigates serotype-specific IgM and IgG responses in relation to opsonophagocytic activity (OPA) following thirteen-valent pneumococcal conjugate (PCV13) vaccination in younger (26–49 y; n = 44), middle-aged (50–64 y; n = 71), and older adults (65–98 y; n = 141). Both OPA and IgM responses declined with age, while IgG responses remained relatively stable. In younger adults, post-PCV13 OPA correlated moderate-to-strong with IgM for 8/13 serotypes and with IgG for only 4/13 serotypes. In contrast, middle-aged and older adults showed strong correlations between OPA and both IgM (10/13 serotypes) and IgG (12/13 serotypes). Overall, post-PCV13 OPA was predominantly associated with IgM levels. These observations suggest that declines in IgM, rather than IgG responses, explain reduced PCV13-induced opsonophagocytic activity in aging adults and may inform future vaccination strategies to enhance protection of older adults against pneumococcal disease.