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<p>Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.</p>

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Product and trial design considerations on the path towards a vaccine to combat opioid overdose

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月19日

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  • Asimenia Angelidou,
  • Jacob A. Koster,
  • Amy C. Sherman,
  • Caitlyn McLoughlin,
  • Pooja Lalwani,
  • Aisling Kelly,
  • Ahsan Saeed,
  • Kerry McEnaney,
  • Lindsey R. Baden,
  • Melissa Brogna,
  • Elissa R. Weitzman,
  • Sharon Levy,
  • David J. Dowling,
  • Ofer Levy

摘要

Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.