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<p>This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regulatory modules, while also presenting computational modelling as a driver for circuit optimisation. The review highlights potential applications towards the production of next-generation biotherapeutics by providing examples on monoclonal antibody glycosylation control, CAR-T cell therapy safety, and gene therapy viral vector yields.</p><p></p>

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Mammalian synthetic gene circuits for biopharmaceutical development & manufacture

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月2日

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  • Sheryl Li Yan Lim,
  • Sofia Gialamoidou,
  • Rajinder Kaur,
  • Ioscani Jimenez del Val

摘要

This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regulatory modules, while also presenting computational modelling as a driver for circuit optimisation. The review highlights potential applications towards the production of next-generation biotherapeutics by providing examples on monoclonal antibody glycosylation control, CAR-T cell therapy safety, and gene therapy viral vector yields.