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<p>Microplastics (MPs) present in a wide range of foods are a food safety concern due to their potential toxicity, yet effective approaches to enhance MPs clearance in the body remain lacking. Here, we first connected MPs excretion capacity to gut microbiota composition through a cross-sectional study of 138 individuals. Differential abundance and genomic variation of <i>Lactiplantibacillus plantarum</i> were observed between low- and high-excretion individuals. With this insight, we isolated <i>L. plantarum</i> PD01 from a high-excretion donor. In mice fed a mixed-MPs diet formulated to reflect human exposure, colonization with <i>L. plantarum</i> PD01 reduced 66.90% of PVC, 56.17% of PET, 91.35% of PS and 49.97% of PE remaining in the intestinal tract. Additionally, <i>L. plantarum</i> PD01 strengthened intestinal barrier integrity, promoted short-chain fatty acid production, alleviated inflammation, and restored gut microbiota dysbiosis caused by Mix-MPs. In vitro assays further validated PD01’s high capacity for MPs adsorption, protection of Caco-2 cells from MPs-induced damage, and reduction of MPs translocation in <i>Caenorhabditis elegans</i>. Collectively, our study uncovered specific gut microbiota features in humans with high MPs excretion and proposes a probiotic intervention strategy to reduce MPs accumulation and toxicity in the body.</p>

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Lactiplantibacillus plantarum PD01 from high excretion donor functions as a natural defense against microplastic toxicity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月4日

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  • Long Zhao,
  • Yuebiao Feng,
  • Junpeng Li,
  • Bidan Yu,
  • Xuee Wu,
  • Feng Zhao,
  • Song Huang,
  • Ruihua Dong

摘要

Microplastics (MPs) present in a wide range of foods are a food safety concern due to their potential toxicity, yet effective approaches to enhance MPs clearance in the body remain lacking. Here, we first connected MPs excretion capacity to gut microbiota composition through a cross-sectional study of 138 individuals. Differential abundance and genomic variation of Lactiplantibacillus plantarum were observed between low- and high-excretion individuals. With this insight, we isolated L. plantarum PD01 from a high-excretion donor. In mice fed a mixed-MPs diet formulated to reflect human exposure, colonization with L. plantarum PD01 reduced 66.90% of PVC, 56.17% of PET, 91.35% of PS and 49.97% of PE remaining in the intestinal tract. Additionally, L. plantarum PD01 strengthened intestinal barrier integrity, promoted short-chain fatty acid production, alleviated inflammation, and restored gut microbiota dysbiosis caused by Mix-MPs. In vitro assays further validated PD01’s high capacity for MPs adsorption, protection of Caco-2 cells from MPs-induced damage, and reduction of MPs translocation in Caenorhabditis elegans. Collectively, our study uncovered specific gut microbiota features in humans with high MPs excretion and proposes a probiotic intervention strategy to reduce MPs accumulation and toxicity in the body.