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<p>Flavonoids are major bioactive constituents of <i>Lycium</i> L. with diverse pharmacological activities. This review summarizes recent advances in the extraction, characterization, and biological functions of <i>Lycium</i> flavonoids (LyFs). Evidence indicates that LyFs exert antioxidant, anti-inflammatory, and immunomodulatory effects via pathways such as NF-κB and Keap1–Nrf2/ARE. Notably, LyFs act as functional prebiotics by modulating gut microbiota and short-chain fatty acid production, supporting intestinal and metabolic health.</p>

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Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月4日

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  • Tian Lan,
  • Kexin Zhou,
  • Guozhen Duan,
  • Yuxin Zhang,
  • Yonggui Ma,
  • Guanghui Fan,
  • Youchao Qi

摘要

Flavonoids are major bioactive constituents of Lycium L. with diverse pharmacological activities. This review summarizes recent advances in the extraction, characterization, and biological functions of Lycium flavonoids (LyFs). Evidence indicates that LyFs exert antioxidant, anti-inflammatory, and immunomodulatory effects via pathways such as NF-κB and Keap1–Nrf2/ARE. Notably, LyFs act as functional prebiotics by modulating gut microbiota and short-chain fatty acid production, supporting intestinal and metabolic health.