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<p>Using Swedish register data, we estimated the proportion of individuals with first-episode psychosis (FEP) who would be eligible to participate in a typical neurobiological study and found that only 39% met criteria. Eligible and ineligible individuals differed on sociodemographic variables and two-year outcome measures (inpatient admission, work disability). Our findings suggest that neurobiological studies may yield samples that are not fully representative of the wider FEP population, potentially limiting generalisability.</p>

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Generalizability of findings from neurobiological studies of individuals with first-episode psychosis: a cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月9日

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  • Alexis E. Cullen,
  • Maria Lee,
  • Pontus Josefsson,
  • Carl M. Sellgren,
  • Sophie Erhardt,
  • Ellenor Mittendorfer-Rutz,
  • Simon Cervenka

摘要

Using Swedish register data, we estimated the proportion of individuals with first-episode psychosis (FEP) who would be eligible to participate in a typical neurobiological study and found that only 39% met criteria. Eligible and ineligible individuals differed on sociodemographic variables and two-year outcome measures (inpatient admission, work disability). Our findings suggest that neurobiological studies may yield samples that are not fully representative of the wider FEP population, potentially limiting generalisability.