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<p>There is evidence that sorptive clays have been used since prehistory as materials to treat skin abrasions and wounds. Despite this, there is a paucity of studies that systematically address the efficacy of defined clays in improving skin wound healing. In this study, we tested the hypothesis that a well-defined synthetic smectite clay, Laponite, enhances healing in a delayed skin wound healing model. Full-thickness skin wounds were made in the back skin of <i>db/db</i> and wild-type male adult mice (8–10 weeks), and Laponite clay gels or controls of phosphate-buffered saline (PBS) or alginate were applied after 24 h and held in place with a semi-occlusive dressing. Although Laponite treatment did not accelerate macroscopic wound closure, it significantly improved healing quality, including re-epithelialisation, epithelial cell division, epithelial thickness and fibroblast invasion, compared with PBS- or alginate-treated <i>db/db</i> mice. Moreover, hair follicle anagen was stimulated in proximity to Laponite-treated wounds, but was absent in PBS- or alginate-treated wounds. Neutrophil infiltration at day 18 was also reduced. In contrast to alginate, in which VEGF improved wound healing, VEGF in Laponite showed negligible additional benefit. These data indicate a role for synthetic nanoclay gels in wound healing.</p>

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Nanoclay gels promote re-epithelialization and improve the quality of skin wound healing in a diabetic mouse model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月23日

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  • Daniel J. Page,
  • Zilian Fan,
  • Claire E. Clarkin,
  • Rajopal Mani,
  • Yang-Hee Kim,
  • Jonathan I. Dawson,
  • Nicholas D. Evans

摘要

There is evidence that sorptive clays have been used since prehistory as materials to treat skin abrasions and wounds. Despite this, there is a paucity of studies that systematically address the efficacy of defined clays in improving skin wound healing. In this study, we tested the hypothesis that a well-defined synthetic smectite clay, Laponite, enhances healing in a delayed skin wound healing model. Full-thickness skin wounds were made in the back skin of db/db and wild-type male adult mice (8–10 weeks), and Laponite clay gels or controls of phosphate-buffered saline (PBS) or alginate were applied after 24 h and held in place with a semi-occlusive dressing. Although Laponite treatment did not accelerate macroscopic wound closure, it significantly improved healing quality, including re-epithelialisation, epithelial cell division, epithelial thickness and fibroblast invasion, compared with PBS- or alginate-treated db/db mice. Moreover, hair follicle anagen was stimulated in proximity to Laponite-treated wounds, but was absent in PBS- or alginate-treated wounds. Neutrophil infiltration at day 18 was also reduced. In contrast to alginate, in which VEGF improved wound healing, VEGF in Laponite showed negligible additional benefit. These data indicate a role for synthetic nanoclay gels in wound healing.