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<p>Effective treatment of mature scars remains a clinical challenge due to limited remodeling strategies. This study evaluated the efficacy and mechanisms of hair follicle micro-particle skin grafting in a prospective trial involving 40 scar patients. (Trial registration: Chinese Clinical Trial Registry, PID300363) Participants were allocated to receive either FUE-derived hair follicle micro-graft transplantation combined with punch excision or punch excision alone. After six months, the transplantation group showed significantly greater reductions in scar volume, lower Vancouver Scar Scale scores at 3 and 6 months, and better alleviation of pain and itching compared to controls. Histological analysis revealed that transplantation induced epidermal thickening, enhanced cell proliferation, and increased type IV collagen deposition at the epidermal-dermal junction. Transcriptomic profiling further revealed that these regenerative effects were associated with activation of the PI3K-AKT signaling pathway, suggesting a potential role in scar remodeling. These findings demonstrate that hair follicle micro-particle grafting is a clinically effective approach for scar remodeling, offering a promising therapeutic strategy to improve both aesthetic and functional outcomes.</p>

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Hair follicle micro-particle skin grafting induces scar remodeling via PI3K-AKT signaling: a randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月4日

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  • Zhongxin Sun,
  • Jie Long,
  • Xifei Qian,
  • Chunsheng Hou,
  • Weili Xu,
  • Rui Yan,
  • Ruibin Hu,
  • Jufang Zhang,
  • Xin Wang

摘要

Effective treatment of mature scars remains a clinical challenge due to limited remodeling strategies. This study evaluated the efficacy and mechanisms of hair follicle micro-particle skin grafting in a prospective trial involving 40 scar patients. (Trial registration: Chinese Clinical Trial Registry, PID300363) Participants were allocated to receive either FUE-derived hair follicle micro-graft transplantation combined with punch excision or punch excision alone. After six months, the transplantation group showed significantly greater reductions in scar volume, lower Vancouver Scar Scale scores at 3 and 6 months, and better alleviation of pain and itching compared to controls. Histological analysis revealed that transplantation induced epidermal thickening, enhanced cell proliferation, and increased type IV collagen deposition at the epidermal-dermal junction. Transcriptomic profiling further revealed that these regenerative effects were associated with activation of the PI3K-AKT signaling pathway, suggesting a potential role in scar remodeling. These findings demonstrate that hair follicle micro-particle grafting is a clinically effective approach for scar remodeling, offering a promising therapeutic strategy to improve both aesthetic and functional outcomes.