Scholarlink

<p>Repairing osteochondral tissue is challenging due to its hierarchical structure, mechanical heterogeneity, and the need for spatial control over stem cell differentiation. Advances in tissue engineering have facilitated the development of biphasic cartilage-bone integrated scaffolds for osteochondral repair. The cartilage layer, composed of an IGF-1-loaded polydopamine-ZIF8/HAMA hydrogel, mimicked native tissue and enabled controlled cytokine release. This layer promoted M2 macrophage polarization, enhanced BMSC migration and chondrogenesis, and improved cartilage anabolism. The subchondral bone layer was a nanoclay (XLS)-functionalized 3D bioglass scaffold, which provided superior mechanical strength and supported osteogenic differentiation. These layers were integrated via partial interpenetration of the HAMA hydrogel. Importantly, in vivo studies confirmed that our biphasic scaffold effectively promoted osteochondral defects regeneration in a rat lower femoral osteochondral defect model. Collectively, this biphasic scaffold system presents a promising therapeutic strategy for osteochondral tissue regeneration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月3日

查看全文
  • Hao Yu,
  • Wei Wang,
  • Hongning Wang,
  • Wenyi Zhang,
  • Yan Zheng,
  • Luya Chen,
  • Shenbin Huang,
  • Wentao Yan,
  • Qingqing Yao

摘要

Repairing osteochondral tissue is challenging due to its hierarchical structure, mechanical heterogeneity, and the need for spatial control over stem cell differentiation. Advances in tissue engineering have facilitated the development of biphasic cartilage-bone integrated scaffolds for osteochondral repair. The cartilage layer, composed of an IGF-1-loaded polydopamine-ZIF8/HAMA hydrogel, mimicked native tissue and enabled controlled cytokine release. This layer promoted M2 macrophage polarization, enhanced BMSC migration and chondrogenesis, and improved cartilage anabolism. The subchondral bone layer was a nanoclay (XLS)-functionalized 3D bioglass scaffold, which provided superior mechanical strength and supported osteogenic differentiation. These layers were integrated via partial interpenetration of the HAMA hydrogel. Importantly, in vivo studies confirmed that our biphasic scaffold effectively promoted osteochondral defects regeneration in a rat lower femoral osteochondral defect model. Collectively, this biphasic scaffold system presents a promising therapeutic strategy for osteochondral tissue regeneration.