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<p>Melanocyte stem cells (McSCs) are a crucial melanocyte reservoir within the hair follicle niche. This review provides an overview of the processes for McSC quiescence and activation. Because McSCs closely interact with hair follicle stem cells, we have focused on this interaction. Given the high prevalence of hair graying, the McSC system serves as a model for cellular aging. Here, we highlight current research on the mechanisms of hair graying.</p>

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Dissecting the boundary of quiescence and activation of murine melanocyte stem cells in the hair follicle niche

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月3日

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  • Tatsuya Ogawa,
  • Min Chen,
  • Soung-Hoon Lee,
  • Denise L. Gay,
  • Mayumi Ito

摘要

Melanocyte stem cells (McSCs) are a crucial melanocyte reservoir within the hair follicle niche. This review provides an overview of the processes for McSC quiescence and activation. Because McSCs closely interact with hair follicle stem cells, we have focused on this interaction. Given the high prevalence of hair graying, the McSC system serves as a model for cellular aging. Here, we highlight current research on the mechanisms of hair graying.