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<p>Peripheral nerve injuries beyond 5 cm lack effective treatments. Functional nerve guidance conduits (NGCs) have emerged as transformative tools orchestrating regeneration by leveraging Schwann cell (SC)-centric mechanisms. This review comprehensively analyzes how NGC designs modulate SC behavior through three synergistic axes: physical cues, biochemical signaling, and bioelectric regulation. By enhancing microenvironmental regulation, next-generation NGCs aim to surpass autograft efficacy, offering scalable solutions for functional nerve recovery and improved patient outcomes.</p>

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Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月26日

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  • Keyue Yang,
  • Shujian Yang,
  • Xiaofeng Teng,
  • Xinkun He,
  • Tao Sun,
  • Hong Chen

摘要

Peripheral nerve injuries beyond 5 cm lack effective treatments. Functional nerve guidance conduits (NGCs) have emerged as transformative tools orchestrating regeneration by leveraging Schwann cell (SC)-centric mechanisms. This review comprehensively analyzes how NGC designs modulate SC behavior through three synergistic axes: physical cues, biochemical signaling, and bioelectric regulation. By enhancing microenvironmental regulation, next-generation NGCs aim to surpass autograft efficacy, offering scalable solutions for functional nerve recovery and improved patient outcomes.