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<p>Corneal diseases are the third leading cause of blindness worldwide. Descemet’s Membrane Endothelial Keratoplasty (DMEK) is the preferred surgical technique for treating corneal endothelial disorders, relying heavily on high-quality donor tissue. However, the scarcity of suitable donor tissue and the sensitivity of endothelial cells remain significant challenges. This review explores the current state of DMEK, focusing on advancements in tissue engineering as a promising solution to improve outcomes and address donor limitations.</p>

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Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月14日

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  • Sarah Barbara Zwingelberg,
  • Gizem Karabiyik,
  • Paul Gehle,
  • Melanie von Brandenstein,
  • Sabina Eibichova,
  • Christian Lotz,
  • Florian Groeber-Becker,
  • Daniel Kampik,
  • Ula Jurkunas,
  • Gerd Geerling,
  • Gregor Lang

摘要

Corneal diseases are the third leading cause of blindness worldwide. Descemet’s Membrane Endothelial Keratoplasty (DMEK) is the preferred surgical technique for treating corneal endothelial disorders, relying heavily on high-quality donor tissue. However, the scarcity of suitable donor tissue and the sensitivity of endothelial cells remain significant challenges. This review explores the current state of DMEK, focusing on advancements in tissue engineering as a promising solution to improve outcomes and address donor limitations.