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<p>This study assessed feasibility and effects of a randomised two-week, at-home intervention with phase-targeted auditory stimulation (PTAS) of slow waves in Parkinson’s disease (PD). We reproduced previously reported enhancement of slow wave activity and confirmed indications of improved patient-reported outcomes. Together with the high adherence and data quality, this suggests that home-based PTAS protocols are a feasible method for investigating the long-term therapeutic potential of deep sleep enhancement in PD.</p>

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Home-based deep sleep modulation in Parkinson’s disease: extension study on long-term feasibility and sleep-related outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Jana Horlacher,
  • Nora-Hjördis Moser,
  • Simon J. Schreiner,
  • Renske Sassenburg,
  • Lydia Kämpf,
  • Sophia D. Schibler,
  • Valentino Mutschler,
  • Esther Werth,
  • Philipp Valko,
  • Jelena Skorucak,
  • Laura Ferster,
  • Walter Karlen,
  • Reto Huber,
  • Christian R. Baumann,
  • Angelina Maric

摘要

This study assessed feasibility and effects of a randomised two-week, at-home intervention with phase-targeted auditory stimulation (PTAS) of slow waves in Parkinson’s disease (PD). We reproduced previously reported enhancement of slow wave activity and confirmed indications of improved patient-reported outcomes. Together with the high adherence and data quality, this suggests that home-based PTAS protocols are a feasible method for investigating the long-term therapeutic potential of deep sleep enhancement in PD.