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<p><i>GBA1</i> variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how <i>GBA1</i> genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.</p>

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Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Pierfrancesco Mitrotti,
  • Micol Avenali,
  • Carlo Alberto Artusi,
  • Rosa De Micco,
  • Giulia Giannini,
  • Rosaria Calabrese,
  • Luca Gallo,
  • Caterina Galandra,
  • Claudia Ledda,
  • Alice Mascia,
  • Mattia Siciliano,
  • Francesco Pagliuca,
  • Luisa Sambati,
  • Valeria Sant’Elia,
  • Gianfranco Vornetti,
  • Giovanna Calandra-Buonaura,
  • Leonardo Lopiano,
  • Raffaele Lodi,
  • Alessandro Tessitore,
  • Marco Bozzali,
  • Enza Maria Valente

摘要

GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.