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<p>This study aimed to compare the qualitative and quantitative measurement of dorsal nigral hyperintensity (DNH) and its diagnostic efficacy for Parkinson’s disease (PD) between 7 T MRI sequences: the combined liquid and blood vessel attenuation with refined double echo steady state (CLEAR-DESS) and susceptibility-weighted imaging (SWI). Following sequence simulation and optimization, a prospective study enrolled 33 PD patients and 52 healthy controls, all undergoing 7 T MRI with CLEAR-DESS and SWI. Four blinded observers qualitatively assessed image quality and DNH visibility, while two independent readers performed quantitative analyses of signal-to-noise (SNR) and contrast-to-noise ratios (CNR). Excellent inter-observer agreement was noted for both qualitative assessments. Diagnostic performance at the DNH level showed CLEAR-DESS (4 observers; AUC: 0.90–0.96; sensitivity: 85%–96%; specificity: 88%–94%) significantly outperformed SWI (4 observers; AUC: 0.73-0.85; sensitivity: 65%–70%; specificity: 74%–89%). Similarly, at the patient level, CLEAR-DESS (4 observers; AUC: 0.91–0.96; sensitivity: 91%–94%; specificity: 88%–100%) surpassed SWI (4 observers; AUC: 0.79–0.87; sensitivity: 80%–89%; specificity: 60%–79%). CLEAR-DESS also showed significantly better DNH visualization slices, SNR, and CNR than SWI (all <i>p</i> &lt; 0.001). The 7T CLEAR-DESS sequence provides superior DNH visualization and PD diagnostic performance compared to SWI, indicating its potential as a preferred choice for DNH evaluation.</p><p></p>

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Superior dorsal nigral hyperintensity depiction at 7 T MRI using CLEAR-DESS improves diagnosis performance of Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Sai Li,
  • Ruiting Chen,
  • Qing Li,
  • Yicheng Hsu,
  • Jiaqi He,
  • Yihang Su,
  • Dongcui Wang,
  • Hao Zhou,
  • Weiwei Zhang,
  • Li Meng,
  • Shulin Liu,
  • Jingyi Tang,
  • Chenyu Li,
  • Peng Lei,
  • Long Qian,
  • Jianxun Qu,
  • Wu Xing,
  • Harrison X. Bai,
  • Weihua Liao

摘要

This study aimed to compare the qualitative and quantitative measurement of dorsal nigral hyperintensity (DNH) and its diagnostic efficacy for Parkinson’s disease (PD) between 7 T MRI sequences: the combined liquid and blood vessel attenuation with refined double echo steady state (CLEAR-DESS) and susceptibility-weighted imaging (SWI). Following sequence simulation and optimization, a prospective study enrolled 33 PD patients and 52 healthy controls, all undergoing 7 T MRI with CLEAR-DESS and SWI. Four blinded observers qualitatively assessed image quality and DNH visibility, while two independent readers performed quantitative analyses of signal-to-noise (SNR) and contrast-to-noise ratios (CNR). Excellent inter-observer agreement was noted for both qualitative assessments. Diagnostic performance at the DNH level showed CLEAR-DESS (4 observers; AUC: 0.90–0.96; sensitivity: 85%–96%; specificity: 88%–94%) significantly outperformed SWI (4 observers; AUC: 0.73-0.85; sensitivity: 65%–70%; specificity: 74%–89%). Similarly, at the patient level, CLEAR-DESS (4 observers; AUC: 0.91–0.96; sensitivity: 91%–94%; specificity: 88%–100%) surpassed SWI (4 observers; AUC: 0.79–0.87; sensitivity: 80%–89%; specificity: 60%–79%). CLEAR-DESS also showed significantly better DNH visualization slices, SNR, and CNR than SWI (all p < 0.001). The 7T CLEAR-DESS sequence provides superior DNH visualization and PD diagnostic performance compared to SWI, indicating its potential as a preferred choice for DNH evaluation.