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<p>Circadian disruption is increasingly recognized as a significant contributor to Parkinson’s disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy’s potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.</p>

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The biological clock in parkinson’s disease: mechanisms and chronotherapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月9日

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  • Hong Liu,
  • Hao Ling,
  • Kangchao Sun,
  • Kun Yang,
  • Wenzhen Du,
  • Yuxiu Ma,
  • Yaru Wang,
  • Kai Wang,
  • Ying Liu,
  • Long Niu

摘要

Circadian disruption is increasingly recognized as a significant contributor to Parkinson’s disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy’s potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.