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<p>Parkinson’s disease (PD) presents a challenge, with neuroinflammation and immune dysregulation central to its pathogenesis. This review examines TREM2—a microglial receptor governing phagocytosis, metabolic adaptation, and immune phenotypes—as an important orchestrator of innate immunity across PD, with roles that appear stage- and context-dependent. We synthesize structure, signaling, and heterogeneity; integrate single-cell multi-omics, animal models, and clinical data; outline conserved mechanisms; and consider translational implications as an investigational biomarker and therapeutic target, emphasizing spatiotemporal dynamics.</p>

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Parkinson’s disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月13日

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  • Keyuan Hou,
  • Zhaowu An,
  • Yuxiang Xu,
  • Jing Wang,
  • Meiru Zhou,
  • Ye Liu,
  • Xianfeng Zhu,
  • Jianshe Wei

摘要

Parkinson’s disease (PD) presents a challenge, with neuroinflammation and immune dysregulation central to its pathogenesis. This review examines TREM2—a microglial receptor governing phagocytosis, metabolic adaptation, and immune phenotypes—as an important orchestrator of innate immunity across PD, with roles that appear stage- and context-dependent. We synthesize structure, signaling, and heterogeneity; integrate single-cell multi-omics, animal models, and clinical data; outline conserved mechanisms; and consider translational implications as an investigational biomarker and therapeutic target, emphasizing spatiotemporal dynamics.