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<p>Previous studies link lower physical activity with incident Parkinson’s disease (PD) but rely on self-reported data and fail to address reverse causation. This study used accelerometer-derived daily step count, an objective measure of physical activity, to examine its association with incident PD in the UK Biobank, within successive periods of follow-up. PD cases were identified through hospital inpatient and death data, and associated with machine learning-derived step counts using Cox regression models, adjusted for age, sex, demographic and lifestyle factors. For 94,696 valid participants and a median follow-up of 7.9 years, 407 incident PD cases occurred. Every 1000 steps higher were associated with 8% lower risk of PD (hazard ratio 0.92, 95% confidence interval 0.89–0.94). However, this association was no longer statistically significant when excluding follow-up periods closer to the time of accelerometer wear, suggesting that low activity may be an early marker, but not a risk factor for PD.</p>

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Daily steps are a predictor of, but perhaps not a risk factor for Parkinson’s disease: findings from the UK Biobank

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月24日

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  • Aidan Acquah,
  • Andrew Creagh,
  • Valentin Hamy,
  • Alaina Shreves,
  • Charilaos Zisou,
  • Charlie Harper,
  • Stefan van Duijvenboden,
  • Chrystalina Antoniades,
  • Derrick Bennett,
  • David Clifton,
  • Aiden Doherty

摘要

Previous studies link lower physical activity with incident Parkinson’s disease (PD) but rely on self-reported data and fail to address reverse causation. This study used accelerometer-derived daily step count, an objective measure of physical activity, to examine its association with incident PD in the UK Biobank, within successive periods of follow-up. PD cases were identified through hospital inpatient and death data, and associated with machine learning-derived step counts using Cox regression models, adjusted for age, sex, demographic and lifestyle factors. For 94,696 valid participants and a median follow-up of 7.9 years, 407 incident PD cases occurred. Every 1000 steps higher were associated with 8% lower risk of PD (hazard ratio 0.92, 95% confidence interval 0.89–0.94). However, this association was no longer statistically significant when excluding follow-up periods closer to the time of accelerometer wear, suggesting that low activity may be an early marker, but not a risk factor for PD.