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<p>Whether distinct blood metabolomic profiles can distinguish Parkinson’s disease (PD) patients from healthy controls (HC) is still a matter of debate. Here, we employed ¹H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patients and HC. Compared to HC, PD patients showed: (1) higher glutamine, serine, pyruvate and lower α-ketoglutarate levels (<sup>1</sup>H-NMR); (2) higher glycine and lower glutamic acid concentrations (UPLC/MS). Several pathways associated with amino acids, mitochondrial and antioxidant metabolism emerged as dysregulated in PD. Our findings highlight a prominent disruption of cellular bioenergetic pathways and amino acid homeostasis in PD.</p>

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Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson’s disease patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月25日

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  • Jacopo Gervasoni,
  • Carmen Marino,
  • Alberto Imarisio,
  • Lavinia Santucci,
  • Enza Napolitano,
  • Tommaso Nuzzo,
  • Isar Yahyavi,
  • Micol Avenali,
  • Michela Cicchinelli,
  • Gabriele Buongarzone,
  • Caterina Galandra,
  • Marta Picascia,
  • Manuela Grimaldi,
  • Claudio Pacchetti,
  • Francesco Errico,
  • Anna Maria D’Ursi,
  • Andrea Urbani,
  • Enza Maria Valente,
  • Alessandro Usiello

摘要

Whether distinct blood metabolomic profiles can distinguish Parkinson’s disease (PD) patients from healthy controls (HC) is still a matter of debate. Here, we employed ¹H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patients and HC. Compared to HC, PD patients showed: (1) higher glutamine, serine, pyruvate and lower α-ketoglutarate levels (1H-NMR); (2) higher glycine and lower glutamic acid concentrations (UPLC/MS). Several pathways associated with amino acids, mitochondrial and antioxidant metabolism emerged as dysregulated in PD. Our findings highlight a prominent disruption of cellular bioenergetic pathways and amino acid homeostasis in PD.