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<p>Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson’s disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.</p>

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Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月17日

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  • Brendan Santyr,
  • Alexandre Boutet,
  • Mohamad Abbass,
  • Artur Vetkas,
  • Jürgen Germann,
  • Afis Ajala,
  • Jianwei Qiu,
  • Gavin J. B. Elias,
  • Can Sarica,
  • Andrew Z. Yang,
  • Ibrahim Alhashyan,
  • Suneil K. Kalia,
  • Alfonso Fasano,
  • Andres M. Lozano

摘要

Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson’s disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.