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<p>Isolated REM sleep behavior disorder (iRBD) is a prodrome of α-synucleinopathies like Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The best marker for prediction of lead time to phenoconversion is reduced striatal dopamine transporter (DaT)-binding, unavailable for most patients. This study investigated EEG alpha peak frequency (APF) slowing – an established marker of cognitive deterioration – as a severity marker in iRBD patients. In 320 patients clinically suspected of RBD 3-night-polysomnography was performed. After exclusion of 131 patients, mainly due to psychotropic medication, three groups were studied: Non-Syn – motor behavior unrelated to RBD (<i>n</i> = 34); iRBD (<i>n</i> = 122); RBD converted to overt α-synucleinopathies (PD = 19; DLB = 14). Data show in patients with iRBD significant correlations between APF, DaT-binding ratios and cognition. The strong correlation of APF &lt; 8 Hz with caudate DaT-binding (<i>r</i> = 0.50–0.65) suggests, APF could be an easy-to-use severity marker for counseling patients on lead time until possible conversion to overt <i>α</i>-synucleinopathy especially in DLB.</p>

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EEG alpha peak frequency: cognitive impairment severity marker in isolated REM sleep behavior disorder

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Sophia Schopp,
  • Jan de Zeeuw,
  • Sophia Stotz,
  • Martin Haberecht,
  • Katy Sahra Weihrich,
  • Michail Plotkin,
  • Frederik Bes,
  • Dieter Kunz

摘要

Isolated REM sleep behavior disorder (iRBD) is a prodrome of α-synucleinopathies like Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The best marker for prediction of lead time to phenoconversion is reduced striatal dopamine transporter (DaT)-binding, unavailable for most patients. This study investigated EEG alpha peak frequency (APF) slowing – an established marker of cognitive deterioration – as a severity marker in iRBD patients. In 320 patients clinically suspected of RBD 3-night-polysomnography was performed. After exclusion of 131 patients, mainly due to psychotropic medication, three groups were studied: Non-Syn – motor behavior unrelated to RBD (n = 34); iRBD (n = 122); RBD converted to overt α-synucleinopathies (PD = 19; DLB = 14). Data show in patients with iRBD significant correlations between APF, DaT-binding ratios and cognition. The strong correlation of APF < 8 Hz with caudate DaT-binding (r = 0.50–0.65) suggests, APF could be an easy-to-use severity marker for counseling patients on lead time until possible conversion to overt α-synucleinopathy especially in DLB.