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<p>Neurodegeneration in Parkinson’s disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapies. As part of Healthy Brain Ageing (HeBA), we implemented a stepwise, population-based screening to identify people at high risk of developing PD. Residents (<i>n</i> = 158,818; 50-80 years) in and around Kassel, Germany were invited to complete an online survey with questions for prodromal symptoms and risk factors. An individual risk score was calculated (International Parkinson and Movement Disorder Society criteria). Selected individuals received a smell test. 8001 of 8774 survey responses were valid; the response rate to the smell test mailings (<i>n</i> = 3021) was 90%. Hyposmic participants (<i>n</i> = 1019) had more subjective hyposmia and subjective memory impairment (<i>p</i> &lt; 0.01). Follow-up visits will validate the recruitment strategy and monitor conversion to manifest PD. Our recruitment strategy identifies people who might be at risk for PD.</p>

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Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Sebastian Schade,
  • Soumyabrata Ghosh,
  • Alicia Garrido,
  • Philipp Mahlknecht,
  • Tainá M. Marques,
  • Corinne G. C. Horlings,
  • Sonja R. Jónsdóttir,
  • Elisabeth Lang,
  • Claire Pauly,
  • Kavita Rege,
  • Susana Schnell,
  • Maritta Starke,
  • Horst Hakelberg,
  • Eduardo Tolosa,
  • Claudia Trenkwalder,
  • Tamara Wicke,
  • Gregor Bletzacher,
  • Atbin Djamshidian,
  • Hannah Egger,
  • Iris Egner,
  • Fernanda Farfan,
  • Tobias Fischnaller,
  • Lena Gatterer,
  • Valentin Groues,
  • Somaye Hajian-Tilaki,
  • Beatrice Heim,
  • Sahra Henze,
  • Florian Krismer,
  • Simon Leiter,
  • Kathrin Marini,
  • Deborah Mcintyre,
  • Ulf Nehrbass,
  • Alastair Noyce,
  • Clarissa P. C. Gomes,
  • Noelia Peña Arauzo,
  • Daniel F. Pilco-Janeta,
  • Rajesh Rawal,
  • Susanne Scaglione,
  • Sabine Schmitz,
  • Reinhard Schneider,
  • Anette Schrag,
  • Katharìna Schwarzovà,
  • Klaus Seppi,
  • Verena Seppi,
  • Raquel Severino,
  • Cristina Simonet,
  • Ruxandra Soare,
  • Heike Stockner,
  • Christoph Theyer,
  • Elodie Thiry,
  • Olena Tsurkalenko,
  • Ludmilla Vasilev,
  • Carlos Vega,
  • Liliana Vilas Boas,
  • Laura Zamarian,
  • Rejko Krüger,
  • Maria J. Marti,
  • Werner Poewe,
  • Venkata P. Satagopam,
  • Brit Mollenhauer

摘要

Neurodegeneration in Parkinson’s disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapies. As part of Healthy Brain Ageing (HeBA), we implemented a stepwise, population-based screening to identify people at high risk of developing PD. Residents (n = 158,818; 50-80 years) in and around Kassel, Germany were invited to complete an online survey with questions for prodromal symptoms and risk factors. An individual risk score was calculated (International Parkinson and Movement Disorder Society criteria). Selected individuals received a smell test. 8001 of 8774 survey responses were valid; the response rate to the smell test mailings (n = 3021) was 90%. Hyposmic participants (n = 1019) had more subjective hyposmia and subjective memory impairment (p < 0.01). Follow-up visits will validate the recruitment strategy and monitor conversion to manifest PD. Our recruitment strategy identifies people who might be at risk for PD.