Scholarlink

<p>Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, and its antagonist BBG mitigates 6-OHDA-induced dopaminergic neuron death. This review discusses P2X7R’s structure, neural functions, PD-related mechanisms, and therapeutic potential as a targert.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月5日

查看全文
  • Shizhuang Wei,
  • Xiaoyu Song,
  • Yakui Mou,
  • Ting Yang,
  • Yao Wang,
  • Hanrui Wang,
  • Chao Ren,
  • Xicheng Song

摘要

Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, and its antagonist BBG mitigates 6-OHDA-induced dopaminergic neuron death. This review discusses P2X7R’s structure, neural functions, PD-related mechanisms, and therapeutic potential as a targert.