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<p>Senile osteoporotic fractures pose a major clinical challenge due to age-related immune and skeletal dysfunctions that critically impair bone healing. Advanced biomaterials capable of compensating for impaired osteogenesis and modulating immune responses are therefore urgently needed. In this study, a biodegradable Mg-1Dy alloy was prepared via low-temperature extrusion for potential orthopedic applications. The alloy exhibited an ultimate tensile strength of 275.9<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\pm 1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mo>±</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation> MPa and controlled degradation behavior, which was supported by a Dy-enriched surface product layer. The immunomodulatory effect of this material has been studied, and the results show that within a concentration range of 8 mM, magnesium ions can inhibit the pro-inflammatory M1 phenotype in macrophages and promote their transformation into the anti-inflammatory M2 phenotype, thereby participating in the regulation of the NF-kB pathway. In the mouse model of senile osteoporotic fractures, compared with the control group, the Mg-1Dy alloy enhanced the mineralization and bone integration of osteocytes. These results suggest that the Mg-1Dy alloy can modulate the immune microenvironment to support bone repair, underscoring its potential value in treating fractures in elderly patients with osteoporosis.</p>

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Biodegradable lean Mg-Dy alloy enhances bone repair in senile osteoporotic fractures by modulating macrophage mediated immune microenvironment

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月17日

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  • Shibo Zhou,
  • Xuanxin Chen,
  • Zhenyang Cai,
  • Xuerui Jing,
  • Hui Shi,
  • Tao Chen,
  • Yulong Wu

摘要

Senile osteoporotic fractures pose a major clinical challenge due to age-related immune and skeletal dysfunctions that critically impair bone healing. Advanced biomaterials capable of compensating for impaired osteogenesis and modulating immune responses are therefore urgently needed. In this study, a biodegradable Mg-1Dy alloy was prepared via low-temperature extrusion for potential orthopedic applications. The alloy exhibited an ultimate tensile strength of 275.9 \(\pm 1\) ± 1 MPa and controlled degradation behavior, which was supported by a Dy-enriched surface product layer. The immunomodulatory effect of this material has been studied, and the results show that within a concentration range of 8 mM, magnesium ions can inhibit the pro-inflammatory M1 phenotype in macrophages and promote their transformation into the anti-inflammatory M2 phenotype, thereby participating in the regulation of the NF-kB pathway. In the mouse model of senile osteoporotic fractures, compared with the control group, the Mg-1Dy alloy enhanced the mineralization and bone integration of osteocytes. These results suggest that the Mg-1Dy alloy can modulate the immune microenvironment to support bone repair, underscoring its potential value in treating fractures in elderly patients with osteoporosis.