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<p>This study assessed osteointegration and degradation of 3D-printed porous pure iron (Fe) versus titanium (Ti) interference screws in porcine anterior cruciate ligament (ACL) reconstruction over 12 months. Twelve pigs were assigned to Fe (experimental) or Ti (control) groups and euthanized at 3-, 6-, or 12-month post-surgery. Osteointegration was evaluated via micro-computed tomography, biomechanical tests measured ACL failure load, and histology examined bone and tissue integration. No significant differences in ACL failure load were noted between groups. Fe implants showed significantly greater bone volume fraction, bone surface density, and intersection-to-total surface area (<i>P</i> = 0.025, 0.047, 0.021). Minimal degradation of Fe implants was observed, with stable implant volumes and histological confirmation of osteoid attachment. Median ambulation time was shorter with Fe implants (5 weeks) than with Ti implants (11 weeks; <i>P</i> = 0.075). Findings demonstrate Fe implants’ biocompatibility and enhanced peri-implant osteogenesis, though improved degradation rates are needed.</p>

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Biodegradable porous iron versus titanium interference screws in porcine ACL reconstruction model: a one-year observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Wen-Chih Liu,
  • Hao-Wei Chang,
  • Shin-I Huang,
  • Kuo-Yi Yang,
  • Pei-I Tsai,
  • Chung-Hwan Chen,
  • Yan-Hsiung Wang,
  • Chun-Hsien Ma,
  • Chih-Yu Chen,
  • Yin-Chih Fu

摘要

This study assessed osteointegration and degradation of 3D-printed porous pure iron (Fe) versus titanium (Ti) interference screws in porcine anterior cruciate ligament (ACL) reconstruction over 12 months. Twelve pigs were assigned to Fe (experimental) or Ti (control) groups and euthanized at 3-, 6-, or 12-month post-surgery. Osteointegration was evaluated via micro-computed tomography, biomechanical tests measured ACL failure load, and histology examined bone and tissue integration. No significant differences in ACL failure load were noted between groups. Fe implants showed significantly greater bone volume fraction, bone surface density, and intersection-to-total surface area (P = 0.025, 0.047, 0.021). Minimal degradation of Fe implants was observed, with stable implant volumes and histological confirmation of osteoid attachment. Median ambulation time was shorter with Fe implants (5 weeks) than with Ti implants (11 weeks; P = 0.075). Findings demonstrate Fe implants’ biocompatibility and enhanced peri-implant osteogenesis, though improved degradation rates are needed.