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<p>Transistor-based biochemical sensors are promising for biomarker detection, offering local signal amplification and compact form factors for miniaturized systems. However, many of these devices are optimized for single-analyte readout, and multiplexed sensing often increases system complexity. Moreover, these platforms rely on relatively rigid substrates, limiting conformal integration with soft biological tissues. Here, we present an ultrathin, multi-gate organic electrochemical transistor (OECT) and demonstrate a proof-of-concept, insertable-format platform for multiplexed biomarker sensing. The device was fabricated on a 4-μm-thick ultrathin parylene substrate and incorporates two gold gate electrodes independently functionalized with distinct aptamers, enabling two-analyte multiplexing on a single OECT channel. Each aptamer showed selective recognition of its target biomarker, and target binding was transduced at the gate and amplified as a measurable modulation of the OECT channel current. We integrated the device into a pill-shaped structure and demonstrated its functionality through ex vivo experiments in a porcine small intestine.</p>

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Ultrathin multi-gate organic electrochemical transistors for insertable multianalyte biochemical sensing

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月28日

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  • Tae Jin Mun,
  • Kyung Yeun Kim,
  • YouBin Choi,
  • Heeju Son,
  • Junghyun Cho,
  • Seongchan Kim,
  • Jayoung Kim,
  • Hyojin Lee,
  • Hyejeong Seong,
  • Seung Hwan Ko,
  • Hojeong Jeon,
  • Wonryung Lee

摘要

Transistor-based biochemical sensors are promising for biomarker detection, offering local signal amplification and compact form factors for miniaturized systems. However, many of these devices are optimized for single-analyte readout, and multiplexed sensing often increases system complexity. Moreover, these platforms rely on relatively rigid substrates, limiting conformal integration with soft biological tissues. Here, we present an ultrathin, multi-gate organic electrochemical transistor (OECT) and demonstrate a proof-of-concept, insertable-format platform for multiplexed biomarker sensing. The device was fabricated on a 4-μm-thick ultrathin parylene substrate and incorporates two gold gate electrodes independently functionalized with distinct aptamers, enabling two-analyte multiplexing on a single OECT channel. Each aptamer showed selective recognition of its target biomarker, and target binding was transduced at the gate and amplified as a measurable modulation of the OECT channel current. We integrated the device into a pill-shaped structure and demonstrated its functionality through ex vivo experiments in a porcine small intestine.