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<p>Conventional microneedle-based transdermal delivery is often limited by passive diffusion or endogenous stimuli, offering poor control over release kinetics and insufficient penetration into deep tissues. Here, we report a fully integrated wearable drug delivery system that couples a flexible and stretchable ultrasound-responsive microneedle patch (Us-MP) with a portable, Bluetooth-programmable ultrasound driver. This platform enables on-demand drug release, with rapid delivery within 10 min or sustained release up to 50 h. Moreover, ultrasound-induced directional acoustic streaming at the microneedle tips significantly enhances transdermal penetration. As a proof of concept, this system enabled precise colchicine delivery, producing rapid anti-inflammatory and anti-swelling effects in acute gouty arthritis, as well as long-term therapeutic and preventive efficacy in chronic gouty arthritis. This work establishes a controllable and versatile strategy for personalized transdermal therapy, with potential applications across diverse diseases and stages of progression.</p>

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Wearable ultrasound microneedle patch for on-demand and sustained management of gouty arthritis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月28日

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  • Shuxin Zhang,
  • Zhengming Zhou,
  • Litong Chen,
  • Yu-Jia Zeng,
  • Tailin Xu

摘要

Conventional microneedle-based transdermal delivery is often limited by passive diffusion or endogenous stimuli, offering poor control over release kinetics and insufficient penetration into deep tissues. Here, we report a fully integrated wearable drug delivery system that couples a flexible and stretchable ultrasound-responsive microneedle patch (Us-MP) with a portable, Bluetooth-programmable ultrasound driver. This platform enables on-demand drug release, with rapid delivery within 10 min or sustained release up to 50 h. Moreover, ultrasound-induced directional acoustic streaming at the microneedle tips significantly enhances transdermal penetration. As a proof of concept, this system enabled precise colchicine delivery, producing rapid anti-inflammatory and anti-swelling effects in acute gouty arthritis, as well as long-term therapeutic and preventive efficacy in chronic gouty arthritis. This work establishes a controllable and versatile strategy for personalized transdermal therapy, with potential applications across diverse diseases and stages of progression.