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<p>Skeletal muscle dysfunction during spaceflight arises from combined mechanical and non-gravitational stressors. Here, we modeled solar particle event-like proton irradiation in C2C12 myogenic cells to examine radiation-induced membrane and mechanosensitive channel alterations. Proton exposure increased membrane rigidity in a dose-dependent manner and significantly reduced the pharmacological activatability of Piezo1 channels, identifying membrane-mediated mechanotransduction as a potential contributor to radiation-induced muscle dysfunction.</p>

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Proton radiation impairs mechanotransduction in C2C12 myoblasts

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月14日

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  • Áron Gere,
  • László Szabó,
  • Brigitta Tillmann,
  • Csaba Balogh,
  • Florina Zákány,
  • Tamás Kovács,
  • Péter Nagy,
  • Máté Szarka,
  • László Csernoch,
  • Beatrix Dienes

摘要

Skeletal muscle dysfunction during spaceflight arises from combined mechanical and non-gravitational stressors. Here, we modeled solar particle event-like proton irradiation in C2C12 myogenic cells to examine radiation-induced membrane and mechanosensitive channel alterations. Proton exposure increased membrane rigidity in a dose-dependent manner and significantly reduced the pharmacological activatability of Piezo1 channels, identifying membrane-mediated mechanotransduction as a potential contributor to radiation-induced muscle dysfunction.